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Compounds in development to combat hyperphosphataemia.

Author: HergesellO, RitzE

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the use of phosphate binders for treating hyperphosphatemia in hemodialysis patients. Traditional phosphate binders such as calcium carbonate, calcium acetate, and aluminum-containing binders have side effects, including hypercalcemia and aluminum intoxication. The development of calcium- and aluminum-free binders such as sevelamer and trivalent-iron containing binders is crucial. This review outlines the experimental and clinical data on Fe-III based phosphate binders, suggesting their potential as effective and safe alternatives.
Paper Details　
Original Abstract of the Article :
Hyperphosphataemia in haemodialysis patients is associated with secondary hyperparathyroidism and more importantly with an increased cardiovascular mortality in dialysed patients. Removal of phosphate during dialysis is less than net intestinal uptake. This imbalance results in a positive phosphate ...See full text at original site
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引用元：
https://doi.org/10.1517/13543784.10.12.2185

データ提供：米国国立医学図書館（NLM）

Hyperphosphatemia: A Challenge for Dialysis Patients

Dr. Camel here, venturing into the world of kidney health. Hyperphosphatemia, an excess of phosphate in the blood, is a common problem for people on dialysis. Think of it as an overabundance of sand in the desert, making it difficult for your body to function properly. This condition is linked to increased cardiovascular risk in dialysis patients, a threat as formidable as a desert sandstorm.

New Phosphate Binders: Finding a Solution

This review explores the challenges of treating hyperphosphatemia in dialysis patients, particularly the limitations of traditional phosphate binders. These binders can have side effects like hypercalcemia (too much calcium) or aluminium intoxication, making it difficult to find the right balance, like navigating a desert landscape where you need to find the right mix of sand and water. The article highlights the development of new phosphate binders, like sevelamer and trivalent-iron based compounds, offering potential solutions to this complex problem.

Managing Phosphate Levels: A Long Journey

Hyperphosphatemia is a serious condition that requires careful monitoring and management. This review suggests that new phosphate binders could offer a safer and more effective way to manage phosphate levels in dialysis patients. It's like finding a new, more reliable camel caravan to help you navigate the desert of hyperphosphatemia.

Dr. Camel's Conclusion

The development of new phosphate binders is a positive step forward in the treatment of hyperphosphatemia. It offers hope for dialysis patients struggling with this condition and may help them navigate the desert of their health challenges with greater ease.

Date :
  1. Date Completed 2002-03-12
  2. Date Revised 2019-09-16
Further Info :

Pubmed ID

11772314

DOI: Digital Object Identifier

10.1517/13543784.10.12.2185

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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