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Original Abstract of the Article :
Ranolazine is a novel drug that has shown promise in the treatment of cardiovascular disease. Ranolazine exerts its effect by shifting myocardial energy metabolism away from free fatty acids and toward glucose as the substrate for production of adenosine triphosphate. Preclinical data have confirmed...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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引用元：
https://doi.org/10.1517/13543784.11.1.117
データ提供：米国国立医学図書館（NLM）
Ranolazine: A New Player in Cardiovascular Disease Treatment
Ranolazine is a novel medication that has shown promise in the treatment of cardiovascular disease. It works by shifting myocardial energy metabolism away from fatty acids and towards glucose, potentially reducing myocardial ischemic injury. This review summarizes the preclinical and clinical evidence supporting the use of ranolazine in cardiovascular disease.
A Novel Approach to Heart Health
Preclinical studies have demonstrated the potential of ranolazine to reduce myocardial ischemic injury in various animal models. Clinical trials have confirmed its anti-ischemic effects, particularly in patients with chronic ischemic heart disease, without causing the typical reduction in blood pressure and heart rate seen with traditional anti-ischemic agents. This makes ranolazine a potentially valuable addition to existing therapies, as it can provide anti-ischemic benefits without adding to the risks of hypotension or bradycardia.
Expanding the Therapeutic Arsenal for Heart Disease
As a cardiologist, I'm excited by the potential of ranolazine. This review provides a comprehensive overview of the research supporting its use in cardiovascular disease. The absence of significant hemodynamic effects makes it a promising option for patients who cannot tolerate traditional anti-ischemic medications. It's a reminder that the field of cardiovascular medicine is constantly evolving, with new therapies emerging to improve patient care. This research is like a refreshing spring in the desert, offering hope for new and effective treatments for heart disease.
Dr.Camel's Conclusion
Ranolazine's unique mechanism of action and its potential to improve myocardial energy metabolism offer a promising new approach to cardiovascular disease management. This research is a testament to the ongoing efforts of researchers to develop innovative therapies for improving heart health. It's a reminder that the journey toward a healthier heart is a continuous journey of discovery.
Date :
- Date Completed 2003-12-11
- Date Revised 2019-09-16
Further Info :
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English
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