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Antihistamines in late-phase clinical development for allergic disease.

Author: SalmunLuis M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Desloratadine and mizolastine are the most widely studied among the newer H(1) antagonists currently in clinical development. Both have a rapid onset of action, and desloratadine has demonstrated clinical efficacy in AR, CIU and seasonal asthma. Desloratadine has several advantages over other H(1) antagonists in that it has proven decongestant activity, a sparing effect on the use of bronchodilators (beta(2)-agonists) and a low potential for drug interactions.
Paper Details　
Original Abstract of the Article :
Allergic rhinitis (AR) is a global health concern and shares a high comorbidity with asthma. Recent research suggests that different allergic diseases, such as AR, asthma, allergic conjunctivitis and chronic idiopathic urticaria (CIU), are evoked by common pathological mechanisms characterised by th...See full text at original site
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引用元：
https://doi.org/10.1517/13543784.11.2.259

データ提供：米国国立医学図書館（NLM）

Antihistamines: A Journey Towards Better Allergy Management

Allergic rhinitis (AR), commonly known as hay fever, is a prevalent condition that can significantly impact daily life. [Antihistamines] are a cornerstone of allergy treatment, but the development of these medications has been an ongoing quest to improve effectiveness and safety. This study explores the evolution of antihistamines and highlights some promising new agents in clinical development.

The Evolution of Antihistamines: A Quest for Improved Efficacy and Safety

This research provides a valuable overview of the advancements in antihistamine development. It emphasizes the need for newer anti-allergic agents that have a wider range of action and improved safety profiles. The study highlights several promising new antihistamines, including [desloratadine] and [mizolastine], that show potential for effectively treating allergic diseases.

Living with Allergies: A Journey of Relief and Resilience

As a camel, I have encountered my fair share of irritants in the desert, from prickly plants to biting insects. The challenges of living with allergies can be similar, but advancements in allergy treatment offer hope for those seeking relief from these bothersome symptoms.

Dr.Camel's Conclusion

This study underscores the ongoing pursuit of more effective and safer antihistamines for treating allergies. The development of new agents like desloratadine and mizolastine holds promise for improving allergy management and enhancing the quality of life for those affected by allergic diseases.

Date :
  1. Date Completed 2003-07-25
  2. Date Revised 2019-09-16
Further Info :

Pubmed ID

11829715

DOI: Digital Object Identifier

10.1517/13543784.11.2.259

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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