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[Clinical usefulness of ondansetron injection in patients receiving cancer chemotherapy].

Author: FujiiTsuneo, FurueHisashi, IkedaMasanori, RikimaruToru, TaguchiTetsuo, TsukagoshiShigeru

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Overview

This study evaluated the effectiveness of ondansetron (OND) for preventing chemotherapy-induced emesis. The study found that OND is effective in reducing the incidence and severity of emesis, and it also improves quality of life for patients. The study also found that the necessary dose and duration of chemotherapy can be affected by other factors, such as blood disorder or renal disorder, in addition to emesis.
Paper Details　
Original Abstract of the Article :
Before and after launch of 5-HT3, antagonist, necessary dose and duration of chemotherapy were compared between the patients who were confirmed to have undergone chemotherapy before the launch of 5-HT3 antagonist (retrospective group) and the ones currently using ondansetron (OND) for chemotherapy-i...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/11865633

データ提供：米国国立医学図書館（NLM）

Clinical Usefulness of Ondansetron Injection in Patients Receiving Cancer Chemotherapy

Chemotherapy-induced nausea and vomiting (CINV) is a distressing side effect of cancer treatment. This study examines the clinical usefulness of ondansetron, a 5-HT3 receptor antagonist, in managing CINV. The researchers compared the necessary dose and duration of chemotherapy between patients who received chemotherapy before the availability of ondansetron and those who currently use ondansetron for CINV. They also conducted a survey on quality of life (QOL) and questionnaires to assess the impact of ondansetron on patient and medical staff experiences.

Ondansetron: Improving Patient QOL and Reducing Workload

The study found that ondansetron significantly improved patient QOL and reduced the workload of medical staff. While ondansetron did not directly influence the necessary dose or duration of chemotherapy, it did have a positive impact on managing CINV and reducing the occurrence of adverse events such as blood disorders and renal dysfunction. This, in turn, allowed patients to receive their chemotherapy regimen more effectively.

Optimizing Cancer Treatment

This research underscores the importance of effective antiemetic control in cancer treatment. Ondansetron has proven to be a valuable tool in managing CINV, improving patient QOL and streamlining the chemotherapy process. This research highlights the significant impact of managing side effects on patient outcomes and healthcare efficiency.

Dr.Camel's Conclusion

Just as a camel can navigate harsh desert conditions by seeking shade and water, ondansetron provides a much-needed respite from the unpleasant side effects of chemotherapy. This research highlights the importance of effective symptom management in improving patient well-being and optimizing cancer treatment.

Date :
  1. Date Completed 2002-03-05
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

11865633

DOI: Digital Object Identifier

11865633

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Languages

Japanese

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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