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A randomised trial to compare the efficacy and safety of Felodipine (Plendil) and Nifedipine (Adalat) retard in patients with mild-to-moderate hypertension.

Author: DanbauchiS S, MbakwemA C, ObodoJ O, OkeD A, OkeahialamB N, OnwubereB J

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compares the efficacy and tolerability of Felodipine extended-release and Nifedipine retard in managing mild-to-moderate hypertension. Both drugs were effective in lowering blood pressure, but Felodipine was better tolerated.
Paper Details　
Original Abstract of the Article :
The efficacy and tolerability of Felodipine extended-release was compared with Nifedipine retard in the management of patients with mild-to-moderate hypertension. A total of one hundred and thirty three patients were screened out of which one hundred and twenty-one patients were enrolled in a 9-week...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/11885871

データ提供：米国国立医学図書館（NLM）

Comparing Felodipine and Nifedipine for Hypertension

This research dives into the world of hypertension, a condition where blood pressure is consistently too high. The study aimed to compare the effectiveness and safety of two common medications: Felodipine (Plendil) and Nifedipine (Adalat) retard, in treating patients with mild to moderate hypertension. The researchers enrolled 121 patients in a 9-week study and randomly assigned them to receive either Felodipine or Nifedipine. They carefully monitored their blood pressure and looked for any side effects.

The study concluded that both medications were effective in lowering blood pressure, but Felodipine was better tolerated. Imagine this: Felodipine is like a gentle camel, calmly carrying the weight of hypertension, while Nifedipine is more like a fiery steed, powerful but requiring more careful handling.

Felodipine: A Smoother Ride for Hypertension

The results showed that Felodipine reduced blood pressure by 20/14 mmHg after three weeks and by 24/16 mmHg after six weeks. This is a significant reduction, indicating that Felodipine is a good choice for managing hypertension. The fact that Felodipine was better tolerated is particularly important, as it can improve patients' quality of life and encourage them to stay on their medication regimen.

Managing Hypertension: A Long Journey

High blood pressure can lead to various health problems, including heart disease and stroke. Managing hypertension is an important part of maintaining good health. While both Felodipine and Nifedipine are effective, Felodipine seems to offer a smoother ride, with fewer side effects.

Dr. Camel's Conclusion

This research adds to our understanding of how to manage hypertension. Choosing the right medication can make a big difference in a patient's health and well-being. Felodipine, with its effectiveness and better tolerability, emerges as a promising option, especially for those who are sensitive to side effects. Remember, just like a camel needs to navigate the desert, managing hypertension requires a thoughtful approach and the right tools.

Date :
  1. Date Completed 2002-04-09
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

11885871

DOI: Digital Object Identifier

11885871

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・Side Effects of felodipine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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