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Efficacy of highly active antiretroviral therapy in HIV-1 infected children.

Author: FraaijPieter L A, de GrootRonald, van RossumAnnemarie M C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review examines paediatric clinical studies using HAART for HIV-1 infection. Virological response rates were variable, while immunological response rates were more uniform. Side effects were generally mild and transient.
Paper Details　
Original Abstract of the Article :
Although the reduction in HIV-1-related deaths with highly active antiretroviral therapy (HAART) is similar in adults and children, the extent of the changes in two important surrogate markers HIV-1 RNA levels and CD4+ T cell counts, differs widely. In most paediatric studies virological response ra...See full text at original site
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引用元：
https://doi.org/10.1016/s1473-3099(02)00183-4

データ提供：米国国立医学図書館（NLM）

Tackling HIV-1 in Children: Exploring the Efficacy of Highly Active Antiretroviral Therapy (HAART)

This review explores the challenges and triumphs of treating HIV-1 infection in children using highly active antiretroviral therapy (HAART). The researchers, like dedicated healers in a bustling desert marketplace, analyzed data from 23 paediatric clinical studies, seeking to understand the factors that influence the effectiveness of HAART in children. The review highlights the complexities of treating HIV-1 in children, emphasizing the need for personalized approaches that consider individual factors and drug pharmacokinetics.

The Evolving Landscape of HIV-1 Treatment

This review provides a comprehensive overview of the evolving landscape of HIV-1 treatment in children. The findings, like a tapestry woven from diverse threads of research, reveal that while HAART has significantly reduced HIV-1-related deaths in children, the virological response rates are often lower than those observed in adults. The review underscores the need for ongoing research to improve treatment strategies and optimize drug dosages for children.

Navigating the Challenges of HIV-1 Treatment in Children

This review highlights the unique challenges of treating HIV-1 infection in children. The study emphasizes the importance of considering individual factors, such as drug pharmacokinetics and adherence to treatment regimens, when developing treatment strategies. Just as a skilled caravan leader navigates the desert, healthcare providers must work closely with children and their families to ensure optimal treatment outcomes.

Dr.Camel's Conclusion

This review provides a valuable overview of the challenges and triumphs of treating HIV-1 infection in children using highly active antiretroviral therapy (HAART). The findings, like a beacon of hope in the desert of HIV-1 research, highlight the need for personalized approaches that consider the unique characteristics of each child and the evolving nature of the disease. Ongoing research is crucial to improve treatment outcomes and ensure a brighter future for children living with HIV-1.

Date :
  1. Date Completed 2002-03-26
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

11901656

DOI: Digital Object Identifier

10.1016/s1473-3099(02)00183-4

SNS
PICO Info
in preparation
Languages

English

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