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Induction of apoptosis by cladribine (2-CdA), gemcitabine and other chemotherapeutic drugs on CD34+/CD38+ and CD34+/CD38- hematopoietic progenitor cells: selective effects of doxorubicin and 2-CdA with protection of immature cells.

Author: BoehrerSimone, BojungaJoerg, ChowKai U, FauthFlorian, HoelzerDieter, MartinHans, MitrouParis S, RummelMathias J, SchneiderBernd, StielerManuela, WeidmannEckhart

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study examines the effects of various chemotherapeutic drugs on the apoptosis of stem cells. Doxorubicin and cladribine selectively induce apoptosis in more mature CD34+/CD38+ stem cells while protecting the less differentiated CD34+/CD38- cells. This suggests that these drugs may be effective and safe alternatives for ex vivo purging of autologous grafts.
Paper Details　
Original Abstract of the Article :
Due to the emerging role of high dose chemotherapy with stem cell rescue and ex vivo purging in hematological diseases, we examined the effect of chemotherapeutic drugs on the rate of apoptosis in more mature CD34+/CD38+ and less differentiated CD34+/CD38- stem cells. CD34+ cells were obtained by ce...See full text at original site
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引用元：
https://doi.org/10.1080/10428190290006198

データ提供：米国国立医学図書館（NLM）

Chemotherapeutic Drugs and Hematopoietic Progenitor Cells: A Balancing Act

The use of [high-dose chemotherapy] followed by [stem cell rescue] is a common treatment strategy in [hematological diseases]. This study investigates the [effects of various chemotherapeutic drugs on the rate of apoptosis in CD34+/CD38+ and CD34+/CD38- hematopoietic progenitor cells]. The authors incubated [CD34+ cells obtained from healthy donors and patients] with different concentrations of [doxorubicin, mitoxantrone, mafosphamide, cladribine, and gemcitabine] and found that [doxorubicin and cladribine selectively induce apoptosis in more mature CD34+/CD38+ progenitors while simultaneously protecting CD34+/CD38- progenitors].

Chemotherapy: A Balancing Act for Hematopoietic Progenitor Cells

The study’s results suggest that [doxorubicin and cladribine might be efficient alternatives in ex vivo purging of autologous grafts] and [safe components in primary treatment schedules of lymphomas or prior to stem cell harvest] due to their [low stem cell toxicity].

Navigating the Desert of Chemotherapy

This research is like a guide to the desert of chemotherapy, highlighting the delicate balance between destroying cancer cells and preserving healthy cells. It’s essential to [carefully select chemotherapy agents] and [monitor their effects] to minimize damage to [hematopoietic progenitor cells].

Dr.Camel's Conclusion

This study is like a camel caravan navigating the vast desert of chemotherapy. It reveals the importance of choosing the right path and understanding the effects of different therapies on the delicate balance of hematopoietic progenitor cells. This research offers valuable insights into the world of cancer treatment, reminding us that finding solutions often requires a careful balance and a thorough understanding of the terrain.

Date :
  1. Date Completed 2003-07-11
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

11999573

DOI: Digital Object Identifier

10.1080/10428190290006198

Related Literature

Article Analysis
・Effects of cladribine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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