Paper Details

  1. Home
  2. Paper Details

Comparison of physical and emotional side effects of progesterone or medroxyprogesterone in early postmenopausal women.

Author: BrizendineLouann, CummingsJennifer A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This 91-day, single-blind pilot study compared the mood and somatic effects of medroxyprogesterone acetate (MPA) or progesterone combined with conjugated equine estrogen (CEE) in 23 nondepressed, early postmenopausal women. None of the hormone treatments had a detectable effect on mood. MPA users reported more vaginal bleeding and breast tenderness than progesterone users. Neither of the progestogens showed a depressive effect on mood. The lesser side effects of the micronized progesterone-containing regimen suggest that some women may prefer it to an MPA-containing regimen.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To compare the mood and somatic effects during the initial 2 months of medroxyprogesterone acetate (MPA) or progesterone combined with conjugated equine estrogen (CEE) in early postmenopausal women. DESIGN: Twenty-three nondepressed, early postmenopausal women (average age, 52.5 years) c...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1097/00042192-200207000-00006

データ提供：米国国立医学図書館（NLM）

Hormone Therapy: Exploring the Mood Effects of Progesterone

The realm of [hormone replacement therapy (HRT)] is a complex one, with ongoing research exploring the [impact of different hormone combinations] on [women's health]. This study delves into the [mood effects] of [progesterone and medroxyprogesterone acetate (MPA)] in [early postmenopausal women]. Using a [single-blind pilot study], researchers compared the [mood and somatic symptoms] associated with these [two progestogens].

Progesterone: Debunking the Mood Myth

The study found that [neither progesterone nor MPA] had a detectable effect on [mood], challenging the [widely held belief] that [progesterone depresses mood]. This finding provides valuable insights into the [potential benefits and risks] of [progesterone-based HRT] for women transitioning through [menopause]. The study also noted a [lower incidence of side effects] with [micronized progesterone] compared to [MPA].

HRT: A Personalized Approach

This research emphasizes the importance of [individualized HRT] for women experiencing [menopause]. The study suggests that [progesterone] may be a [viable option] for women seeking [HRT] without concerns about [mood disturbances]. However, the authors acknowledge the need for [further research] to explore the [long-term effects] of [progesterone] and [MPA] on [women's health]. It's important for women to [consult with their healthcare providers] to determine the [most suitable HRT] for their unique needs.

Dr. Camel's Conclusion

This study sheds light on the [complex relationship] between [hormones, mood, and menopause]. It's like a [desert flower] blooming amidst the [challenges of hormonal changes], reminding us that [progesterone] might not be the [mood-dampening agent] many believe it to be. This research encourages a [more nuanced understanding] of [HRT] and the importance of [personalized treatment plans] based on individual needs and preferences.

Date :
  1. Date Completed 2002-09-17
  2. Date Revised 2019-11-06
Further Info :

Pubmed ID

12082361

DOI: Digital Object Identifier

10.1097/00042192-200207000-00006

Related Literature

Article Analysis
・Side Effects of medroxyprogesterone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.