Paper Details

  1. Home
  2. Paper Details

Lead mobilization during calcium disodium ethylenediaminetetraacetate chelation therapy in treatment of chronic lead poisoning.

Author: ArroyoMiguel, BarrientosAlberto, CanoMontserrat, FernándezChristina, PratsDolores, Sánchez-FructuosoAna I

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Chronic lead (Pb) poisoning can cause renal insufficiency. This study investigated the effectiveness of disodium monocalcium EDTA in reducing lead levels in rats. Treatment with EDTA significantly reduced lead levels in the brain and kidney, but not in bone. EDTA appears to be a useful chelating agent for lead poisoning, but it may not be effective in removing lead from bone.
Paper Details　
Original Abstract of the Article :
It has long been established that chronic lead (Pb) poisoning is a cause of renal insufficiency. However, although easily diagnosed, there is still no treatment available that will revert this type of poisoning. We report a study performed on 56 male Wistar rats administered Pb in drinking water (50...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1053/ajkd.2002.33913

データ提供：米国国立医学図書館（NLM）

Chelation Therapy: A Complex Solution for Lead Poisoning

[Lead poisoning] is a serious health concern that can have devastating effects on the body. It's like a desert oasis slowly being poisoned by a toxic substance, harming the delicate ecosystem. This study investigates the effectiveness of chelation therapy, a treatment that removes lead from the body, in treating chronic lead poisoning.

A Tug-of-War in the Desert

The researchers used a model of chronic lead poisoning in rats to assess the effectiveness of a chelating agent called EDTA. They found that while EDTA effectively reduced lead levels in critical organs like the brain and kidney, it seemed to have limited impact on lead deposits in bone. This is like trying to remove a persistent poison from a desert oasis – some areas are more readily accessible than others.

Navigating the Challenges

This research highlights the complexities of treating chronic lead poisoning. While chelation therapy can be effective in removing lead from certain tissues, the persistent presence of lead in bone can pose a long-term risk. Further research is needed to develop more effective and comprehensive treatment strategies to address the challenges of chronic lead poisoning.

Dr.Camel's Conclusion

This research emphasizes the complex nature of lead poisoning and the challenges associated with chelation therapy. While this treatment can effectively reduce lead levels in certain organs, the persistent presence of lead in bone poses a significant challenge. Further research is needed to develop more effective and comprehensive approaches to address the long-term consequences of chronic lead poisoning.

Date :
  1. Date Completed 2002-07-17
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

12087561

DOI: Digital Object Identifier

10.1053/ajkd.2002.33913

Related Literature

Article Analysis
・Effective treatment of lead poisoning
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.