Paper Details 
Original Abstract of the Article :
PURPOSE: Both topical diltiazem, a calcium channel blocker, and glyceryl trinitrate, a nitric oxide donor, lower anal pressure and heal two-thirds of chronic anal fissures. This study evaluated the efficacy of diltiazem for fissures that failed to heal with glyceryl trinitrate. METHODS: Consecutive...See full text at original site
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引用元:
https://doi.org/10.1007/s10350-004-6365-z

データ提供:米国国立医学図書館(NLM)

Diltiazem: A New Hope for Glyceryl Trinitrate-Resistant Anal Fissures

Chronic anal fissures, like a persistent crack in the desert floor, can cause significant discomfort and pain. While glyceryl trinitrate, a common treatment, is effective for many patients, some fissures remain resistant to its healing properties. This prospective study explores the potential of diltiazem, a calcium channel blocker, as a treatment option for these stubborn fissures. The researchers examined the effectiveness of diltiazem in patients whose fissures had failed to heal with glyceryl trinitrate. The results showed that diltiazem was an effective treatment for glyceryl trinitrate-resistant anal fissures, offering a beacon of hope for patients struggling with this condition.

Diltiazem: A Powerful Tool for Healing Resistant Fissures

The study found that topical diltiazem effectively lowered anal resting pressure, a key factor contributing to the formation and persistence of anal fissures. The treatment also led to healing in almost half of the patients, suggesting that diltiazem can be a valuable option for those who have not responded to traditional treatments. The research also found that diltiazem was generally well-tolerated, with only a small number of patients experiencing minor side effects.

Navigating the Painful Terrain of Anal Fissures: A New Path to Healing

This research offers a new path to healing for patients with glyceryl trinitrate-resistant anal fissures. Diltiazem, like a skilled guide leading across the desert, effectively reduces pain and promotes healing. This study provides valuable insights into the potential of diltiazem as a treatment option for this challenging condition, offering a glimmer of hope for patients struggling with chronic anal fissures.

Dr.Camel's Conclusion

The desert of chronic anal fissures can be a painful and challenging place to navigate. This research sheds light on the potential of diltiazem as a powerful tool for healing those stubborn fissures that haven't responded to other treatments. Diltiazem offers a refreshing oasis in the desert of anal fissure pain, providing hope for patients seeking relief and promoting healing.

Date :
  1. Date Completed 2002-09-27
  2. Date Revised 2019-07-21
Further Info :

Pubmed ID

12195195

DOI: Digital Object Identifier

10.1007/s10350-004-6365-z

Related Literature

SNS
PICO Info
in preparation
Languages

English

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