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[The potential P300 in the evaluation of the side effects of dexchlorpheniramine].

Author: EsceraC, GrauC, Serra-GrabulosaJ M, Sánchez-TuretM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effects of a single 4 mg dose of dexchlorpheniramine, an antihistamine, on the P300 evoked potential, a measure of cognitive processing. Dexchlorpheniramine was found to have no significant effect on P300 amplitude or latency, suggesting that this dose may not have a significant impact on cognitive function.
Paper Details　
Original Abstract of the Article :
The antihistamine chlorpheniramine presents multiple adverse side effects on the central nervous system. In earlier work it has been observed that a dose equal to the one used in this study alters the evoked potentials PN (processing negativity) and MMN (mismatch negativity), which are, respectively...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/12235557

データ提供：米国国立医学図書館（NLM）

The Potential of P300 in Assessing Dexchlorpheniramine Side Effects

Dexchlorpheniramine, an antihistamine medication, can cause various adverse effects on the central nervous system. This research investigates the effects of a single dose of dexchlorpheniramine on the P300 evoked potential, a measure of cognitive processing. The study employed a double-blind design, comparing the P300 responses in subjects who received dexchlorpheniramine or placebo. The researchers found that dexchlorpheniramine altered the P300 potential, suggesting potential effects on cognitive function.

Exploring the Brain's Response to Medications

This study delves into the intriguing world of cognitive processing and its response to medications. By measuring the P300 potential, the researchers gain insights into the brain's electrical activity and how it might be influenced by dexchlorpheniramine. This research provides valuable information for understanding the potential cognitive side effects of antihistamines and for developing more effective treatment strategies. Imagine this like observing a desert ecosystem – understanding the changes in the environment after a specific intervention reveals valuable insights into its interconnectedness.

Navigating the Side Effects of Antihistamines

This research underscores the importance of understanding the potential side effects of medications, even those seemingly benign, like antihistamines. The researchers' findings suggest that dexchlorpheniramine might have subtle effects on cognitive function, highlighting the need for careful monitoring and consideration of individual patient needs. It's like navigating a desert with a compass – understanding the potential hazards and taking necessary precautions is crucial for a safe journey.

Dr. Camel's Conclusion

This study provides valuable insights into the effects of dexchlorpheniramine on cognitive function, as measured by the P300 potential. The researchers' findings highlight the need for careful monitoring and consideration of individual patient needs when prescribing antihistamines. It's like studying the patterns of sand dunes in a desert – understanding the subtle changes in cognitive function can lead to a more informed and personalized approach to medication use.
Date :
  1. Date Completed 2003-05-14
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

12235557

DOI: Digital Object Identifier

rn2002101

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・Side Effects of chlorpheniramine
SNS
PICO Info
in preparation
Languages

Spanish

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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