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A comparative study of the side effects between pseudoephedrine in Loratadine plus Pseudoephedrine Sulfate Repetabs Tables and loratadine + pseudoephedrine tablet in treatment of allergic rhinitis in Thai patients.

Author: ChochaipanichnonLadda, KerekhanjanarongVirachai, SaengpanichSupinda, SupiyaphunPakpoom

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study compared the adverse reactions of loratadine plus pseudoephedrine sulfate Repetabs (LTD+PSE Repetabs) with loratadine plus pseudoephedrine tablets in treating allergic rhinitis. LTD+PSE Repetabs were found to be well tolerated with fewer adverse effects compared to loratadine plus pseudoephedrine tablets, particularly tremor and insomnia.
Paper Details　
Original Abstract of the Article :
The objective of the study was to evaluate the adverse reactions of Loratadine plus Pseudoephedrine Sulfate Repetabs Tables (LTD+PSE Repetabs) (Loratadine 5 mg + Pseudoephedrine 120 mg) twice daily with that of loratadine (5 mg) twice daily and pseudoephedrine (60 mg) quarter daily in the treatment ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/12322847

データ提供：米国国立医学図書館（NLM）

Comparing the Side Effects of Two Allergy Medications

This study investigates the field of allergology, specifically focusing on the comparative side effects of two common allergy medications. Researchers used a double-blind, parallel-group design to compare Loratadine plus Pseudoephedrine Sulfate Repetabs Tables (LTD+PSE Repetabs) with loratadine and pseudoephedrine tablets in treating allergic rhinitis, a condition causing nasal inflammation. The study involved 56 patients equally divided into two groups, each receiving treatment for 14 days. Both groups were similar in age, gender, weight, and baseline blood pressure and pulse rate. The study's main objective was to determine whether one medication caused fewer side effects than the other.

Loratadine plus Pseudoephedrine Repetabs Showed Fewer Side Effects

The researchers found that the incidence of patients experiencing tremors at day 14 was significantly higher in the loratadine and pseudoephedrine tablet group compared to the LTD+PSE Repetabs group (39% vs. 10.7%, p-value = 0.03). Furthermore, one patient in the loratadine and pseudoephedrine tablet group had to discontinue medication at day 7 due to insomnia. The researchers concluded that LTD+PSE Repetabs was well-tolerated and had fewer adverse effects than the loratadine and pseudoephedrine tablet combination.

Choosing the Right Allergy Medication

This research offers insights into the side effect profiles of different allergy medications. It highlights that even though loratadine and pseudoephedrine are commonly prescribed, the combination of these drugs in a single tablet may lead to a higher incidence of side effects. For individuals experiencing allergies, choosing the right medication is crucial. Before starting any new medication, it's essential to consult with a healthcare professional to discuss potential side effects and find the most suitable treatment option.

Dr.Camel's Conclusion

Just like a camel navigating a vast desert, finding the right path for allergy treatment can be tricky! It's good to know that LTD+PSE Repetabs may be a more comfortable option for some individuals with allergies, leading to fewer side effects. Remember, always seek advice from a healthcare professional to find the best treatment for your specific needs.

Date :
  1. Date Completed 2002-11-05
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

12322847

DOI: Digital Object Identifier

12322847

SNS
PICO Info
in preparation
Languages

English

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