Dose response of intrathecal adenosine in experimental pain and allodynia.

Author: CurryRegina, EisenachJames C, HoodDavid D

Paper Details 
Original Abstract of the Article :
Intrathecal adenosine reduces areas of mechanical hypersensitivity and provides analgesia in patients with neuropathic pain. Adenosine also causes side effects, yet its dose response for either efficacy or side effects has not been examined in double blind studies. We studied two doses of intratheca...See full text at original site
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引用元:
https://doi.org/10.1097/00000542-200210000-00028

データ提供:米国国立医学図書館(NLM)

Intrathecal Adenosine: A Dose-Response Exploration

The world of pain management is constantly evolving, seeking more effective and targeted approaches to alleviate suffering. This study delves into the use of intrathecal adenosine, a neurotransmitter that plays a role in pain modulation, to address experimental pain and allodynia. The researchers aimed to determine the optimal dose of intrathecal adenosine for both efficacy and minimizing side effects.

Intrathecal Adenosine: Exploring the Dose-Response Relationship

This study investigated the effects of two doses of intrathecal adenosine in patients with experimental hypersensitivity. The findings provide valuable information about the dose-response relationship of this drug. The researchers also explored the ability of the adenosine receptor antagonist, aminophylline, to reverse adenosine's effects.

Navigating the Use of Intrathecal Adenosine

This research contributes to our understanding of the potential therapeutic benefits and side effects of intrathecal adenosine. The study highlights the importance of carefully titrating the dose of this drug to maximize efficacy and minimize adverse effects. As with any treatment, it's crucial to discuss potential risks and benefits with your healthcare provider.

Dr. Camel's Conclusion

This study is like a camel traversing a vast desert, seeking the right path to deliver relief from pain. The research helps us understand the dosage sweet spot for intrathecal adenosine, navigating the balance between effectiveness and potential side effects. It's a reminder that finding the right dose for each individual is crucial for maximizing the benefits of this promising treatment approach.

Date :
  1. Date Completed 2002-10-22
  2. Date Revised 2019-06-28
Further Info :

Pubmed ID

12357162

DOI: Digital Object Identifier

10.1097/00000542-200210000-00028

Related Literature

SNS
PICO Info
in preparation
Languages

English

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