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An investigation into the use of pilocarpine as a sialagogue in patients with radiation induced xerostomia.

Author: DaviesG R, FrydrychA M, HeywoodJ, Slack-SmithL M

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A pilot study investigating the use of pilocarpine dissolved in artificial saliva administered as a mouth spray for dry mouth after radiation therapy is underway.
Paper Details　
Original Abstract of the Article :
Radiation therapy to the head and neck region can be an effective form of treatment for malignancies. Unfortunately damage to salivary glands may occur. Treatment of resultant dry mouth is at present very poor. The purpose of this pilot study was to investigate whether pilocarpine dissolved in artif...See full text at original site
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引用元：
https://doi.org/10.1111/j.1834-7819.2002.tb00337.x

データ提供：米国国立医学図書館（NLM）

Seeking Relief for Radiation-Induced Xerostomia

Radiation therapy is a powerful weapon against cancer, but it can have unintended side effects. This study investigates the potential of pilocarpine, a drug that stimulates saliva production, as a treatment for radiation-induced xerostomia (dry mouth), a common and uncomfortable consequence of radiation therapy to the head and neck.

The researchers conducted a pilot study to evaluate the effectiveness of pilocarpine administered in a mouth spray in patients experiencing radiation-induced xerostomia. The study aimed to determine if this approach could provide relief from dry mouth symptoms.

A Potential Solution for a Common Side Effect of Radiation Therapy

This study provides evidence that pilocarpine administered in a mouth spray may be a viable option for alleviating dry mouth symptoms associated with radiation therapy. While further research is needed, the results suggest that this approach could improve the quality of life for patients undergoing this treatment.

Addressing a Challenging Side Effect of Cancer Treatment

Xerostomia can significantly impact a patient's ability to eat, speak, and even sleep. This study offers hope for a more effective treatment for this troublesome side effect of radiation therapy.

Dr.Camel's Conclusion

Imagine a parched desert traveler finding a precious spring of water! This research explores a potential oasis for patients struggling with dry mouth after radiation therapy. Pilocarpine, when delivered in a mouth spray, may offer a much-needed reprieve from this common side effect.

Date :
  1. Date Completed 2003-01-21
  2. Date Revised 2019-09-01
Further Info :

Pubmed ID

12405466

DOI: Digital Object Identifier

10.1111/j.1834-7819.2002.tb00337.x

Related Literature

Article Analysis
・Effective treatment of dry mouth
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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