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Indinavir-induced retinoid-like effects: incidence, clinical features and management.

Author: AlmagroManuel, FonsecaEduardo, García-SilvaJesús, Peña-PenabadCarmen

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Indinavir is the only antiretroviral drug known to cause retinoid-like effects, including paronychia and ingrown toenails. These effects occur in approximately 30% of patients receiving indinavir and are likely dose-dependent. Switching to an antiretroviral regimen without indinavir usually resolves these manifestations.
Paper Details　
Original Abstract of the Article :
Since 1998, many cases of antiretroviral therapy-related paronychia of the toes or fingers and ingrown toenails have been reported. Most of them were related to indinavir. Other indinavir-induced mucocutaneous disorders resembling the adverse effects of systemic retinoid therapy have also been repor...See full text at original site
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引用元：
https://doi.org/10.2165/00002018-200225140-00002

データ提供：米国国立医学図書館（NLM）

Indinavir: A Retinoid-Like Effect with Unexpected Consequences

The world of HIV treatment is continually seeking new and effective therapies. This study explores the potential side effects of indinavir, a commonly used antiretroviral medication. The research delves into the retinoid-like effects observed in some patients treated with indinavir, including paronychia (nail inflammation) and other skin abnormalities. The authors examine the prevalence, clinical features, and management of these adverse effects.

Indinavir: A Cautionary Tale

The study's findings highlight the potential for indinavir to cause retinoid-like effects in some patients. It's a stark reminder that even effective medications can have unexpected side effects. This discovery emphasizes the importance of careful monitoring and prompt intervention when these side effects occur.

Managing Indinavir's Side Effects: A Balancing Act

This research offers valuable insights into the management of indinavir-induced retinoid-like effects. It's a crucial piece of the puzzle in ensuring the safe and effective use of this medication. The study also highlights the importance of considering alternative treatment options when these side effects are persistent or severe.

Dr. Camel's Conclusion

This research is a desert mirage, a glimpse of potential side effects that can arise from seemingly effective treatments. It's a reminder that we must always be vigilant and approach the treatment of complex diseases with caution. It's a testament to the ongoing pursuit of knowledge and the quest for safer and more effective treatments.

Date :
  1. Date Completed 2003-04-25
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

12408731

DOI: Digital Object Identifier

10.2165/00002018-200225140-00002

Related Literature

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・Effects of indinavir
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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