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Rifampin markedly decreases plasma concentrations of praziquantel in healthy volunteers.

Author: MahatthanatrakulWerawath, PunyoJarurat, RidtitidWibool, SunbhanichMethi, WongnawaMalinee

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Praziquantel, a drug used to treat parasitic infections, is metabolized by the hepatic cytochrome P450 (CYP) enzymes. This study investigated the potential pharmacokinetic interaction between praziquantel and rifampin, a potent CYP enzyme inducer. The results suggested that rifampin may decrease the plasma concentrations of praziquantel, indicating a potential for drug interaction.
Paper Details　
Original Abstract of the Article :
Praziquantel is extensively metabolized by the hepatic cytochrome P450 (CYP) enzymes. The CYP3A isoforms are likely to be major enzymes responsible for praziquantel metabolism. Rifampin (INN, rifampicin), a potent enzyme inducer of CYP-mediated metabolism (especially CYP2C9, CYP2C19, and CYP3A4), is...See full text at original site
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引用元：
https://doi.org/10.1067/mcp.2002.129319

データ提供：米国国立医学図書館（NLM）

The Interaction of Rifampin and Praziquantel

This study explores a potential drug interaction between rifampin, an antibiotic, and praziquantel, an antiparasitic drug. The researchers investigated the impact of rifampin on the plasma concentrations of praziquantel in healthy volunteers, finding that rifampin significantly decreases praziquantel levels. This interaction is attributed to rifampin's ability to induce enzymes involved in drug metabolism.

Understanding Drug Interactions

This study highlights the importance of understanding potential drug interactions, particularly when multiple medications are prescribed. It underscores the need for careful monitoring and dose adjustments when patients are taking rifampin and praziquantel together to ensure optimal therapeutic outcomes.

The Importance of Consulting your Healthcare Provider

When taking multiple medications, it's always essential to consult your healthcare provider about potential interactions and any necessary adjustments. By staying informed and communicating openly with your doctor, you can ensure that you receive the best possible care.

Dr.Camel's Conclusion

Like two travelers crossing paths in the vast desert, rifampin and praziquantel can interact in ways that may impact their effectiveness. This study reminds us of the importance of careful navigation when managing multiple medications, ensuring safe and efficient treatment.
Date :
  1. Date Completed 2002-12-12
  2. Date Revised 2018-12-11
Further Info :

Pubmed ID

12426514

DOI: Digital Object Identifier

10.1067/mcp.2002.129319

Related Literature

Article Analysis
・Effects of rifampin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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