Update on fenofibrate.

Author: GuayDavid R P

Paper Details 
Original Abstract of the Article :
Fenofibrate is a fibric acid derivative that has been marketed since the mid-1970's (1998 in the United States). Its active metabolite, fenofibric acid, is responsible for the primary pharmacodynamic effects of the drug: reductions in total plasma cholesterol, low density lipoprotein cholesterol, tr...See full text at original site
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引用元:
https://doi.org/10.1111/j.1527-3466.2002.tb00098.x

データ提供:米国国立医学図書館(NLM)

Fenofibrate: A Look at a Fibric Acid Derivative

Fenofibrate is a medication used to lower cholesterol levels. It's like a camel caravan traversing a vast desert, seeking to reduce the burden of high cholesterol.

This study reviews the effectiveness and safety of fenofibrate, which has been in use since the mid-1970s. It works by activating peroxisome proliferator-activated receptor-alpha (PPAR(alpha)), which helps regulate lipid metabolism.

Fenofibrate has been shown to reduce total cholesterol, low-density lipoprotein cholesterol (LDL), triglycerides, and very low-density lipoprotein (VLDL) concentrations, while increasing high-density lipoprotein cholesterol (HDL) levels. It's like a camel caravan finding a hidden oasis of healthy lipids, restoring balance to the body's desert.

The study also notes that fenofibrate is generally well-tolerated, with common side effects similar to other fibrates. However, ongoing outcome trials are needed to determine its long-term efficacy in reducing cardiovascular disease risk.

The Importance of Cholesterol Management

This study emphasizes the importance of managing cholesterol levels for cardiovascular health. It's like ensuring a safe and smooth journey across the desert - proper cholesterol management can help prevent heart disease, a major threat to health.

Lifestyle Changes and Medication

This study reminds us that maintaining good cardiovascular health requires a combination of lifestyle changes and medication. It's like a wise camel caravan, relying on both its own endurance and the guidance of a skilled leader to reach its destination safely.

Dr.Camel's Conclusion

Fenofibrate offers a valuable tool for managing cholesterol levels, but its long-term impact on cardiovascular health requires further investigation. It’s like a camel caravan embarking on a long journey, with the goal of a healthier heart in sight.
Date :
  1. Date Completed 2003-06-17
  2. Date Revised 2019-11-06
Further Info :

Pubmed ID

12481201

DOI: Digital Object Identifier

10.1111/j.1527-3466.2002.tb00098.x

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PICO Info
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Languages

English

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