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Analgesic effects of morphine and morphine-6-glucuronide in a transcutaneous electrical pain model in healthy volunteers.

Author: DarimontJutta, GeisslingerGerd, LötschJörn, SchmidtHelmut, SkarkeCarsten

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Morphine-6-glucuronide clearly produced analgesic effects, but the high amounts of systemic morphine-6-glucuronide needed to produce the same effects as morphine suggest that morphine-6-glucuronide barely contributes to the central nervous opioid effects after administration of analgesic doses of morphine.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: Our objective was to quantify the extent and time course of the effects of morphine-6-glucuronide and morphine on pain threshold, pain tolerance, pupil diameter, and side effects. METHODS: In a double-blind, placebo-controlled, randomized, 3-way crossover study, 12 healthy volunteers (6 ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/12545149

データ提供：米国国立医学図書館（NLM）

Analgesic Effects of Morphine and Morphine-6-glucuronide in a Transcutaneous Electrical Pain Model in Healthy Volunteers

As a researcher exploring the complexities of pain management, I'm always interested in understanding the mechanisms of action of different analgesics. This study investigates the analgesic effects of morphine and morphine-6-glucuronide, a major metabolite of morphine, using a transcutaneous electrical pain model in healthy volunteers. The authors found that both morphine and morphine-6-glucuronide produced comparable analgesic effects, but with different pharmacokinetic profiles. Morphine-6-glucuronide showed a slower onset of action and a longer duration of effect compared to morphine. This study provides valuable insights into the pharmacodynamic and pharmacokinetic properties of these opioids, offering a more comprehensive understanding of their analgesic actions.

Delving into the Depths of Pain Relief

This study provides a detailed analysis of the analgesic effects of morphine and its major metabolite, morphine-6-glucuronide. The authors' findings highlight the similarities and differences in their analgesic actions, demonstrating that both compounds produce comparable pain relief but with varying pharmacokinetic profiles. This research offers a deeper understanding of the mechanisms of action of these opioids, contributing to a more comprehensive approach to pain management.

Navigating the Sands of Pain Relief

This study underscores the importance of understanding the pharmacokinetic properties of different analgesics. The authors demonstrate that while both morphine and morphine-6-glucuronide produce similar analgesic effects, they exhibit distinct pharmacokinetic profiles. This research emphasizes the need for a more nuanced approach to pain management, considering the individual characteristics of different medications and their impact on patients' experiences.

Dr. Camel's Conclusion

This study provides valuable insights into the pharmacodynamic and pharmacokinetic properties of morphine and morphine-6-glucuronide, offering a more comprehensive understanding of their analgesic actions. The findings highlight the similarities and differences in their effects, suggesting that these opioids may have different applications based on their unique characteristics.

Date :
  1. Date Completed 2003-02-12
  2. Date Revised 2016-11-24
Further Info :

Pubmed ID

12545149

DOI: Digital Object Identifier

S0009923602176065

Related Literature

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PICO Info
in preparation
Languages

English

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