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A randomized, double-blind, placebo-controlled, multicenter study that assessed the endometrial effects of norethindrone acetate plus ethinyl estradiol versus ethinyl estradiol alone.

Author: KempfertNona J, PortmanDavid J, SymonsJames P, WilbornWalter

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Norethindrone acetate effectively protects the endometrium from estrogen-induced hyperplasia. Norethindrone acetate/ethinyl estradiol combinations also significantly reduce endometrial proliferation compared to conjugated equine estrogens/medroxyprogesterone acetate.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: The purpose of this study was to determine the incidence of endometrial hyperplasia in subjects who receive continuous norethindrone acetate and ethinyl estradiol combinations versus unopposed ethinyl estradiol. STUDY DESIGN: Nine hundred forty-five postmenopausal women were randomly sel...See full text at original site
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引用元：
https://doi.org/10.1067/mob.2003.91

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 2003-03-27
  2. Date Revised 2019-06-16
Further Info :

Pubmed ID

12592236

DOI: Digital Object Identifier

10.1067/mob.2003.91

Related Literature

Article Analysis
・Effects of norethindrone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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