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Pyridostigmine enhances glutamatergic transmission in hippocampal CA1 neurons.

Author: BrowneR Orie, FriedmanAlon, PavlovskyLev

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

Pyridostigmine, a carbamate acetylcholinesterase (AChE) inhibitor, is used to treat myasthenia gravis. Although it doesn’t normally cross the blood-brain barrier, studies suggest that it can enter the brain under certain conditions, affecting cortical excitability and gene expression. This study aims to understand the mechanisms of pyridostigmine-induced changes in central neuron excitability.
Paper Details　
Original Abstract of the Article :
Pyridostigmine, a carbamate acetylcholinesterase (AChE) inhibitor, is routinely employed in the treatment of the autoimmune disease myasthenia gravis. Due to its positively charged ammonium group, under normal conditions pyridostigmine cannot cross the blood-brain barrier (BBB) and penetrate the bra...See full text at original site
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引用元：
https://doi.org/10.1016/s0014-4886(02)00016-x

データ提供：米国国立医学図書館（NLM）

Pyridostigmine: A Desert Oasis of Glutamatergic Transmission

This study delves into the effects of pyridostigmine, an acetylcholinesterase (AChE) inhibitor used to treat myasthenia gravis, on glutamatergic transmission in hippocampal CA1 neurons. The authors utilize whole-cell intracellular recordings to investigate the mechanisms underlying pyridostigmine-induced changes in neuronal excitability. The research reveals that pyridostigmine, by increasing free ACh levels, enhances excitatory transmission through a muscarinic receptor-dependent mechanism. The study provides valuable insights into the potential central side effects of pyridostigmine, as well as the underlying mechanisms of action of AChE inhibitors, which have implications for understanding the effects of nerve-gas agents and organophosphate pesticides.

Pyridostigmine: A Complex Oasis of Glutamatergic Transmission

The study reveals that pyridostigmine, commonly used for treating myasthenia gravis, can have unexpected effects on the brain. The research demonstrates that pyridostigmine can enhance glutamatergic transmission in hippocampal neurons, which could contribute to central side effects observed with this drug. The findings highlight the importance of considering the potential central effects of drugs that are primarily used to target peripheral systems.

Navigating the Desert of Drug Side Effects

The desert of drug side effects can be a treacherous landscape for patients and clinicians. This study provides a valuable reminder that drugs intended for peripheral targets can have unexpected effects on the brain. The research highlights the importance of understanding the potential central effects of drugs, particularly those that affect neurotransmission. The findings emphasize the need for vigilance in monitoring patients for both intended and unintended effects of medications.

Dr.Camel's Conclusion

The desert of drug side effects can be unpredictable, but this study sheds light on a previously overlooked aspect of pyridostigmine's effects. The research reveals that this drug can enhance glutamatergic transmission in the brain, potentially contributing to central side effects. This finding emphasizes the importance of considering the potential central effects of drugs, even those primarily intended for peripheral targets.

Date :
  1. Date Completed 2003-03-25
  2. Date Revised 2019-07-22
Further Info :

Pubmed ID

12618125

DOI: Digital Object Identifier

10.1016/s0014-4886(02)00016-x

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PICO Info
in preparation
Languages

English

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