Outcomes with nifedipine GITS or Co-amilozide in hypertensive diabetics and nondiabetics in Intervention as a Goal in Hypertension (INSIGHT).

Author: , BrownMorris, CastaigneAlain, ManciaGiuseppe, PalmerChristopher R, RosenthalTalma, RuilopeLuis M, WagenerGilbert, de LeeuwPeter

Paper Details 
Original Abstract of the Article :
To investigate the impact of treatment on cardiovascular mortality and morbidity, we assessed outcomes in patients with hypertension and diabetes who received co-amilozide or nifedipine in the International Nifedipine GITS Study: Intervention as a Goal in Hypertension. Participants had to be 55 to 8...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/12623939

データ提供:米国国立医学図書館(NLM)

Nifedipine GITS: A Potential First-Line Therapy for Hypertensive Diabetics

Navigating the landscape of hypertension treatment, especially in the presence of diabetes, can be as tricky as navigating a desert sandstorm. This research investigates the effectiveness of nifedipine GITS, a slow-release formulation of nifedipine, in managing cardiovascular complications in hypertensive diabetics. The study compares nifedipine GITS to co-amilozide, a combination of hydrochlorothiazide and amiloride, in a large-scale clinical trial.

Nifedipine GITS Shows Promise in Managing Cardiovascular Complications

The results showed that nifedipine GITS was as effective as diuretic therapy in reducing cardiovascular complications in hypertensive diabetics. This finding is particularly important for patients with diabetes, as they are at a higher risk of cardiovascular disease. The study also revealed that nifedipine-treated patients were less likely to develop new diabetes or experience secondary events, which include all-cause mortality, death from a vascular cause, and death from a non-vascular cause. These findings are encouraging and suggest that nifedipine GITS could be considered as a first-line therapy for hypertensive diabetics.

A New Oasis in Hypertension Management

This research offers a ray of hope for hypertensive diabetics seeking effective and safe treatment options. The findings suggest that nifedipine GITS may be a valuable tool in managing cardiovascular complications and reducing the risk of diabetes-related complications. It is important to note that further research is needed to confirm these findings and to explore the long-term effects of nifedipine GITS on hypertensive diabetics. However, this study provides compelling evidence for the potential benefits of nifedipine GITS in managing this complex condition.

Dr.Camel's Conclusion

This research provides a promising avenue for managing hypertension in patients with diabetes. Nifedipine GITS demonstrates potential as a first-line therapy for hypertensive diabetics, offering effective cardiovascular complication management and a lower risk of diabetes development. Further research is crucial to solidify these findings and explore the long-term effects of this treatment option.

Date :
  1. Date Completed 2003-04-11
  2. Date Revised 2022-03-18
Further Info :

Pubmed ID

12623939

DOI: Digital Object Identifier

01.HYP.0000057420.27692.AD

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PICO Info
in preparation
Languages

English

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