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A systematic review of adverse effects associated with topical treatments for psoriasis.

Author: BrunerChristine R, FeldmanSteven R, FleischerAlan B, VentrapragadaMadhuri

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This review compared the side effects of different topical treatments for mild to moderate psoriasis. Topical corticosteroids caused fewer side effects than vitamin D analogues or tazarotene when used alone. Combinations of treatments generally had more side effects than single treatments, except for the combination of topical steroids and calcipotriene, which reduced irritation. The most common side effects were skin irritation with vitamin D analogues, tazarotene, dithranol, and coal tar, and headache, viral infections, and skin thinning with topical corticosteroids. While topical treatments are generally well-tolerated, excessive use can increase the risk of skin and systemic side effects. Treatment plans should consider both short-term and long-term management goals, as complete clearance is often unrealistic.
Paper Details　
Original Abstract of the Article :
Mild to moderate psoriasis is a disease that can often be treated with topical medications. The diversity of topical therapies and their disparate side effects complicates treatment planning. Our purpose is to compare the rates of adverse events associated with different topical psoriasis treatments...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/12639460

データ提供：米国国立医学図書館（NLM）

A Systematic Review of Adverse Effects Associated with Topical Treatments for Psoriasis

Psoriasis, a chronic skin condition, can be like a relentless desert storm, causing discomfort and affecting a person's quality of life. This study delves into the world of topical treatments for psoriasis, examining the rates of adverse events associated with different medications. Researchers conducted a systematic review of medical literature, analyzing the side effects of various topical treatments, including corticosteroids, vitamin D analogues, tazarotene, dithranol, and coal tar. The study found that corticosteroids generally had fewer adverse reactions compared to other topical treatments. The most common side effects were irritant contact dermatitis, headache, viral infection, and skin atrophy. The study emphasizes the need for careful treatment planning, taking into consideration both short-term management and long-term control of psoriasis.

Navigating the Landscape of Psoriasis Treatment

The study's findings provide valuable insights into the risk-benefit profile of different topical treatments for psoriasis. Understanding the potential side effects of various medications is crucial for clinicians to make informed decisions about treatment plans, minimizing risks while maximizing effectiveness.

Finding the Right Oasis in Psoriasis Treatment

As a researcher, I recognize the challenges faced by individuals with psoriasis. This study highlights the importance of considering not only the effectiveness of topical treatments but also their potential side effects. It's like choosing the right oasis in a vast desert, finding a treatment that provides relief without causing significant harm. Further research is needed to develop safer and more effective treatments for psoriasis, allowing those affected to find lasting relief from this challenging condition.

Dr.Camel's Conclusion

This comprehensive review provides a valuable roadmap for managing psoriasis, emphasizing the importance of understanding the potential risks and benefits of different topical treatments. It underscores the need for ongoing research to discover more effective and safer therapies for this chronic condition.

Date :
  1. Date Completed 2003-04-21
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

12639460

DOI: Digital Object Identifier

12639460

Related Literature

Article Analysis
・Effective treatment of psoriasis
SNS
PICO Info
in preparation
Languages

English

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