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Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients.
Author: HoffbrandA Victor, KhoriatyAdlette I, KoussaSusane, MouradFadi H, Sheikh-TahaMarwan, TaherAli
Original Abstract of the Article :
Desferrioxamine (DFX) alone (40-50 mg/kg/d s.c. over 8-12 h, five times weekly) was compared with combined DFX twice weekly and deferiprone (75 mg/kg/d) over 12 months in previously poorly chelated thalassaemia patients. Serum ferritin fell from 5506 +/- 635 microg/l (mean +/- SEM) to 3998 +/- 604 m...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://doi.org/10.1046/j.1365-2141.2003.04240.x
データ提供：米国国立医学図書館（NLM）
Iron Overload in Thalassaemia: Comparing Chelation Therapies for Optimal Management
Thalassaemia, like a relentless desert heat, presents a unique challenge for patients. This study, like a camel seeking a cool respite, compares the efficacy of desferrioxamine alone and in combination with deferiprone for managing iron overload in thalassaemia patients. The researchers conducted a 12-month study, comparing the two chelation therapies and evaluating their impact on serum ferritin levels and urine iron excretion.
Seeking Balance in the Desert: A Comprehensive Approach to Iron Overload
The study concludes that the combined therapy of desferrioxamine and deferiprone, like a collaborative team of camels navigating a challenging desert terrain, is as effective as desferrioxamine alone for managing iron overload in thalassaemia patients. The study highlights the potential benefits of this combined approach, suggesting a more effective strategy for reducing iron accumulation and minimizing the long-term complications associated with iron overload.
Navigating the Challenges of Thalassaemia Management
This study, like a well-worn path through the desert of thalassaemia management, provides valuable insights for healthcare professionals. It emphasizes the importance of considering personalized chelation therapies, taking into account the individual needs and preferences of each patient. The study also underscores the need for ongoing research to develop more effective and less burdensome chelation therapies for thalassaemia patients.
Dr.Camel's Conclusion
This study, like a caravan traversing the desert of thalassaemia research, highlights the importance of optimizing chelation therapy for iron overload. It showcases the potential benefits of combining desferrioxamine and deferiprone, offering a promising approach for managing iron overload in thalassaemia patients and improving their overall well-being.
Date :
- Date Completed 2003-06-30
- Date Revised 2019-07-05
Further Info :
Related Literature
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