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Angiotensin-I-converting enzyme inhibitors may be an alternative anti-angiogenic strategy in the treatment of liver fibrosis and hepatocellular carcinoma. Possible role of vascular endothelial growth factor.
Author: FukuiHiroshi, KuriyamaShigeki, YoshijiHitoshi
Original Abstract of the Article :
The renin-angiotensin system (RAS) is frequently activated in patients with chronic liver diseases. Angiotensin-II (AT-II), which is produced by angiotensin-converting enzyme (ACE), has many physiological effects, including strong pro-angiogenic activity. AT-II induces the potent angiogenic factor, ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://pubmed.ncbi.nlm.nih.gov/12677092
データ提供:米国国立医学図書館(NLM)
ACE Inhibitors: A New Weapon in the Fight Against Liver Fibrosis and Hepatocellular Carcinoma?
Liver fibrosis, a slow and insidious process, can ultimately lead to cirrhosis and liver cancer. This study delves into the potential role of angiotensin-converting enzyme (ACE) inhibitors in combating these debilitating conditions. The authors explore the intricate connection between the renin-angiotensin system (RAS), angiogenesis, and liver disease, suggesting that ACE inhibitors may offer a promising therapeutic approach.
The researchers meticulously reviewed the literature on ACE inhibitors, highlighting their potential anti-angiogenic effects. They explore the role of ACE inhibitors in suppressing vascular endothelial growth factor (VEGF), a key driver of angiogenesis, and their impact on liver fibrogenesis. This study, like a desert explorer mapping a new territory, provides valuable insights into the potential of ACE inhibitors in treating liver disease.
ACE Inhibitors: A Promising Avenue for Liver Disease Treatment?
This study suggests that ACE inhibitors may offer a promising new avenue for treating liver fibrosis and hepatocellular carcinoma. Their potential anti-angiogenic effects, coupled with their proven safety profile, make them an attractive therapeutic option. This study, like a wellspring in a parched desert, offers a glimmer of hope for those seeking effective treatments for liver disease.
Navigating the Complex Terrain of Liver Disease: A New Path Forward
This study provides valuable insights into the complex landscape of liver disease. The findings suggest that ACE inhibitors may offer a novel and potentially effective approach to combating liver fibrosis and hepatocellular carcinoma. This research, like a compass guiding us through a vast and unforgiving desert, points towards a brighter future for those affected by liver disease.
Dr.Camel's Conclusion
This study explores the potential of ACE inhibitors in treating liver disease, like a desert explorer discovering a hidden oasis. Their anti-angiogenic effects and proven safety profile make them a promising therapeutic option, offering hope for those battling liver fibrosis and hepatocellular carcinoma.
Date :
- Date Completed 2003-08-22
- Date Revised 2018-02-13
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English
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