Angiotensin-I-converting enzyme inhibitors may be an alternative anti-angiogenic strategy in the treatment of liver fibrosis and hepatocellular carcinoma. Possible role of vascular endothelial growth factor.

Author: FukuiHiroshi, KuriyamaShigeki, YoshijiHitoshi

Paper Details 
Original Abstract of the Article :
The renin-angiotensin system (RAS) is frequently activated in patients with chronic liver diseases. Angiotensin-II (AT-II), which is produced by angiotensin-converting enzyme (ACE), has many physiological effects, including strong pro-angiogenic activity. AT-II induces the potent angiogenic factor, ...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/12677092

データ提供:米国国立医学図書館(NLM)

ACE Inhibitors: A New Weapon in the Fight Against Liver Fibrosis and Hepatocellular Carcinoma?

Liver fibrosis, a slow and insidious process, can ultimately lead to cirrhosis and liver cancer. This study delves into the potential role of angiotensin-converting enzyme (ACE) inhibitors in combating these debilitating conditions. The authors explore the intricate connection between the renin-angiotensin system (RAS), angiogenesis, and liver disease, suggesting that ACE inhibitors may offer a promising therapeutic approach.

The researchers meticulously reviewed the literature on ACE inhibitors, highlighting their potential anti-angiogenic effects. They explore the role of ACE inhibitors in suppressing vascular endothelial growth factor (VEGF), a key driver of angiogenesis, and their impact on liver fibrogenesis. This study, like a desert explorer mapping a new territory, provides valuable insights into the potential of ACE inhibitors in treating liver disease.

ACE Inhibitors: A Promising Avenue for Liver Disease Treatment?

This study suggests that ACE inhibitors may offer a promising new avenue for treating liver fibrosis and hepatocellular carcinoma. Their potential anti-angiogenic effects, coupled with their proven safety profile, make them an attractive therapeutic option. This study, like a wellspring in a parched desert, offers a glimmer of hope for those seeking effective treatments for liver disease.

Navigating the Complex Terrain of Liver Disease: A New Path Forward

This study provides valuable insights into the complex landscape of liver disease. The findings suggest that ACE inhibitors may offer a novel and potentially effective approach to combating liver fibrosis and hepatocellular carcinoma. This research, like a compass guiding us through a vast and unforgiving desert, points towards a brighter future for those affected by liver disease.

Dr.Camel's Conclusion

This study explores the potential of ACE inhibitors in treating liver disease, like a desert explorer discovering a hidden oasis. Their anti-angiogenic effects and proven safety profile make them a promising therapeutic option, offering hope for those battling liver fibrosis and hepatocellular carcinoma.

Date :
  1. Date Completed 2003-08-22
  2. Date Revised 2018-02-13
Further Info :

Pubmed ID

12677092

DOI: Digital Object Identifier

69792

Related Literature

SNS
PICO Info
in preparation
Languages

English

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