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[Significance of TPMT activity and TGNs level detection for individualizing 6-mercaptopurine chemotherapy].

Author: ChenJing, GuLong-jun, LiangAi-bin, TangYao-nian, XueHui-liang, YeQi-dong, YeYu-chun, ZhaoJin-cai

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Measuring thiopurine methyltransferase (TPMT) activity before mercaptopurine (6-MP) therapy and thioguanine nucleotides (TGNs) levels during 6-MP therapy may help prevent side effects from drug overdose and individualize 6-MP chemotherapy in children with acute lymphoblastic leukemia (ALL).
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To evaluate the activity and genotype of thiopurine methyltransferase (TPMT) and the concentration of thioguanine nucleotides (TGNs) as parameters for individualizing mercaptopurine (6-MP) therapy. METHODS: Erythrocyte TPMT activity was measured by means of radiochemical assay. Sequence ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/12679004

データ提供：米国国立医学図書館（NLM）

Individualizing Chemotherapy with TPMT Activity and TGNs Levels

This study focuses on the importance of individualizing chemotherapy treatment for acute lymphoblastic leukemia (ALL) patients. Imagine a caravan of camels traveling through the desert – each camel needs a specific amount of water and food to stay healthy. This research explores how to tailor chemotherapy dosage based on patients' individual characteristics.

TPMT Activity and TGNs Levels

The researchers investigated the role of thiopurine methyltransferase (TPMT) activity and thioguanine nucleotide (TGNs) levels in determining the optimal chemotherapy dosage for ALL patients. TPMT activity is like the camel's ability to process water, while TGNs levels represent the amount of water available to the camel. By measuring these factors, doctors can ensure that the camel receives the right amount of water to stay hydrated and thrive.

Precision Medicine in Chemotherapy

This study emphasizes the importance of personalized medicine in chemotherapy. By taking into account individual patient characteristics, doctors can optimize treatment strategies, minimizing side effects and improving outcomes. It's like tailoring the water supply to each camel's needs, ensuring the entire caravan is strong and healthy.

Dr.Camel's Conclusion

This research underscores the importance of tailoring chemotherapy treatment to individual patients, like providing each camel with the specific resources it needs to survive and thrive in the desert. It's a reminder that precision medicine can make a significant difference in the success of cancer treatment.

Date :
  1. Date Completed 2007-05-04
  2. Date Revised 2017-11-16
Further Info :

Pubmed ID

12679004

DOI: Digital Object Identifier

12679004

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SNS
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in preparation
Languages

Chinese

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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