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Short-term exposure to low-dose ritonavir impairs clearance and enhances adverse effects of trazodone.

Author: ByronSusan, ChenGengsheng, CulmKerry E, DailyJohanna P, FogelmanSteven M, GrafJennifer A, GrandaBrian W, GreenblattDavid J, HarmatzJerold S, MertzanisPolyxane, ShaderRichard I, von MoltkeLisa L

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Ritonavir significantly reduced apparent oral clearance of trazodone, prolonged elimination half-life, and increased peak plasma concentrations (mean +/- SE). Coadministration of trazodone with ritonavir increased sedation, fatigue, and performance impairment compared to trazodone plus placebo.
Paper Details　
Original Abstract of the Article :
Antiretroviral agents may participate in drug interactions that influence the efficacy and toxicity of other antiretrovirals, as well as pharmacologic treatments of coincident or complicating diseases. The viral protease inhibitor, ritonavir, may cause drug interactions by inhibiting the activity of...See full text at original site
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引用元：
https://doi.org/10.1177/0091270003251864

データ提供：米国国立医学図書館（NLM）

Ritonavir's Impact on Trazodone Clearance and Adverse Effects

The world of drug interactions is a complex and often unpredictable desert, where seemingly unrelated medications can interact in unexpected ways. This study explores the impact of ritonavir, a medication commonly used to treat HIV infection, on the clearance and adverse effects of trazodone, a drug used to treat depression. The study highlights the need for caution and close monitoring when co-administering these medications, especially in the context of potential drug interactions.

Navigating the Desert of Drug Interactions

The study found that ritonavir significantly impaired the clearance of trazodone, leading to increased levels of the drug in the body. This is like crossing a desert with a camel carrying an additional heavy load, potentially slowing down the journey and increasing the risk of exhaustion. The study also observed an increased occurrence of adverse reactions, such as sedation, fatigue, and performance impairment, when trazodone was co-administered with ritonavir.

Understanding the Hidden Dangers

This study serves as a reminder of the importance of being aware of potential drug interactions. This is like being vigilant in the desert, recognizing the signs of danger and taking precautions to avoid potential hazards. By understanding the potential risks, healthcare providers can make informed decisions about medication regimens, minimizing the chances of encountering unexpected challenges.

Dr. Camel's Conclusion

This study underscores the importance of careful consideration when co-administering ritonavir and trazodone. The findings highlight the need for vigilance and close monitoring to navigate the desert of drug interactions and minimize the risk of unforeseen side effects, ensuring a safe and effective journey for patients.

Date :
  1. Date Completed 2003-07-31
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

12723462

DOI: Digital Object Identifier

10.1177/0091270003251864

SNS
PICO Info
in preparation
Languages

English

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