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Use of active vitamin D sterols in patients with chronic kidney disease, stages 3 and 4.

Author: CoburnJack W, MaungHla M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This paper reviews randomized controlled trials and other reported data on the use of active vitamin D sterols, such as calcitriol, alfacalcidol, and doxercalciferol, in the management of secondary hyperparathyroidism in patients with mild-to-moderate renal insufficiency. Data on potential benefits, including improved histologic abnormalities of bone, increased bone mineral density, and a reduction of elevated parathyroid hormone levels, are documented. Risks of such therapy, which include the production of hypercalcemia, more rapid progression of renal insufficiency, and accelerated vascular and soft tissue calcification are also discussed.
Paper Details　
Original Abstract of the Article :
This paper reviews randomized controlled trials and other reported data on the use of the active vitamin D sterols, such as calcitriol, alfacalcidol, and doxercalciferol, in the management of secondary hyperparathyroidism in patients with mild-to-moderate renal insufficiency (stage 3 or 4 chronic ki...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://pubmed.ncbi.nlm.nih.gov/12753265

データ提供：米国国立医学図書館（NLM）

Vitamin D in Chronic Kidney Disease: A Balancing Act in the Desert of Renal Health

Chronic kidney disease (CKD), a serious condition that affects the kidneys' ability to filter waste, is like a slow-moving desert sandstorm, gradually eroding kidney function. This research explores the potential benefits and risks of using active vitamin D sterols, such as calcitriol, in managing secondary hyperparathyroidism, a common complication of CKD.

The researchers, acting as skilled desert guides, review randomized controlled trials and other data on the use of active vitamin D sterols in patients with CKD. They discuss the potential benefits, such as improved bone health and reduced parathyroid hormone levels, while also acknowledging the risks, including hypercalcemia and accelerated vascular calcification.

The study's findings highlight the need for a cautious and individualized approach to vitamin D therapy in patients with CKD. It's crucial to carefully monitor patients for potential side effects and adjust dosages as needed.

The Oasis of Bone Health: Vitamin D's Potential Benefits

The research highlights the potential benefits of active vitamin D sterols in managing secondary hyperparathyroidism in patients with CKD. The researchers observed improvements in bone health and reduced parathyroid hormone levels in some patients receiving vitamin D therapy.

Navigating the Desert of Risks: Balancing Benefits and Side Effects

This research underscores the importance of a careful balancing act when using active vitamin D sterols in patients with CKD. While these medications offer potential benefits, it's crucial to be aware of the risks associated with their use and to closely monitor patients for any adverse effects.

Dr. Camel's Conclusion

In the challenging desert of chronic kidney disease, active vitamin D sterols offer a potential oasis of bone health. However, it's essential to navigate this terrain with caution, balancing the potential benefits against the risks of hypercalcemia and other adverse effects. Individualized monitoring and careful dosage adjustments are crucial for ensuring safe and effective use.

Date :
  1. Date Completed 2004-01-16
  2. Date Revised 2019-01-31
Further Info :

Pubmed ID

12753265

DOI: Digital Object Identifier

S0085-2538(15)49265-8

Related Literature

Article Analysis
・Effects of doxercalciferol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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