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Clinical response to alefacept: results of a phase 3 study of intravenous administration of alefacept in patients with chronic plaque psoriasis.

Author: KruegerG G

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

There is a need for safe and effective psoriasis treatments that provide lasting remission after stopping treatment. Alefacept, a new type of biological agent, has shown long-lasting effectiveness in treating chronic plaque psoriasis. The effectiveness of alefacept is linked to reductions in memory-effector T cells, a type of immune cell involved in psoriasis.
Paper Details　
Original Abstract of the Article :
There is a current lack of safe and effective psoriasis therapies that provide patients with lasting remissions after treatment is discontinued. Alefacept, a novel and selective biological agent, has demonstrated durable efficacy in patients with chronic plaque psoriasis, and its efficacy has been c...See full text at original site
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引用元：
https://doi.org/10.1046/j.1468-3083.17.s2.4.x

データ提供：米国国立医学図書館（NLM）

Clinical Response to Alefacept: Results of a Phase 3 Study of Intravenous Administration of Alefacept in Patients with Chronic Plaque Psoriasis

The journey to manage psoriasis, a chronic skin condition, can feel like a long and arduous desert trek. This study investigates the effectiveness of alefacept, a novel biological therapy, for individuals with chronic plaque psoriasis. The researchers conducted a phase 3 clinical trial to evaluate the efficacy of alefacept administered intravenously to patients with chronic plaque psoriasis. This study, using a rigorous clinical trial methodology, found that alefacept demonstrated significant and durable efficacy in reducing psoriasis symptoms, suggesting a potential breakthrough in psoriasis treatment.

Finding an Oasis in the Desert of Psoriasis: Alefacept Shows Promise

The study's findings suggest that alefacept could offer a new and effective treatment option for individuals with chronic plaque psoriasis. This discovery could provide much-needed relief for those struggling with this challenging skin condition. Imagine finding a hidden oasis in a desolate desert - alefacept could be a similar source of comfort and healing for psoriasis patients.

Hope on the Horizon: Treating Psoriasis with Alefacept

This research offers hope for individuals with chronic plaque psoriasis. The study's findings suggest that alefacept might be a valuable addition to the treatment armamentarium for this condition. It's like finding a new and reliable source of water in a barren desert, offering a chance for sustained relief and improved quality of life. Consult with a dermatologist to explore all available treatment options and determine the most effective path for managing your psoriasis.

Dr. Camel's Conclusion

This phase 3 study provides compelling evidence for the efficacy of alefacept in treating chronic plaque psoriasis. It's like discovering a hidden oasis in the desert of psoriasis research, offering hope and relief for individuals struggling with this condition. The findings suggest that alefacept could be a valuable tool in the fight against psoriasis, potentially leading to improved quality of life for patients.

Date :
  1. Date Completed 2003-11-19
  2. Date Revised 2019-10-25
Further Info :

Pubmed ID

12795771

DOI: Digital Object Identifier

10.1046/j.1468-3083.17.s2.4.x

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・Effective treatment of psoriasis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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