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Acute pharmacological effects of temazepam, diphenhydramine, and valerian in healthy elderly subjects.

Author: BustoUsoa E, GlassJennifer R, HerrmannNathan, SprouleBeth A, StreinerDavid

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Temazepam (30 mg) had the most significant effects on sedation and psychomotor ability compared to placebo, diphenhydramine (50 and 75 mg), and valerian (400 and 800 mg). Diphenhydramine also produced sedation, but to a lesser extent than temazepam. Valerian had no significant effects on sedation or psychomotor performance.
Paper Details　
Original Abstract of the Article :
Elderly insomniacs are often treated pharmacologically with benzodiazepines, antihistamines, or natural products. A double-blind, randomized, crossover, placebo-controlled study was performed to assess the comparative pharmacodynamics of single doses of temazepam (15 and 30 mg), diphenhydramine (50 ...See full text at original site
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引用元：
https://doi.org/10.1097/01.jcp.0000084033.22282.b6

データ提供：米国国立医学図書館（NLM）

The Effects of Temazepam, Diphenhydramine, and Valerian on Healthy Elderly Subjects

Insomnia is a common problem, particularly among older adults. Imagine trying to navigate a desert at night, with the stars barely visible and the sand constantly shifting. Researchers are constantly seeking safe and effective treatments for insomnia, and this study examines the pharmacological effects of several commonly used medications in healthy elderly individuals.

A Comparative Study: Navigating the Desert of Sleep

The study compared the effects of temazepam, diphenhydramine, and valerian on sedation, mood, and psychomotor performance in healthy elderly volunteers. Temazepam was found to have the most significant effects on sedation and psychomotor ability, while valerian had no noticeable effects. These findings provide valuable information about the comparative pharmacodynamics of these medications in older adults.

Finding the Right Path: Choosing the Best Treatment

This study highlights the importance of carefully considering the potential effects of medications used for insomnia, especially in older adults. The findings emphasize the need for individualised treatment approaches to ensure safety and effectiveness. Understanding the different effects of these medications can help patients and their healthcare providers choose the most appropriate treatment option.

Dr.Camel's Conclusion

This study provides important insights into the effects of commonly used medications for insomnia in older adults. It highlights the need for a careful and individualized approach to treatment, taking into account the potential for side effects and individual differences in response to medications. By carefully navigating the desert of sleep, patients and their healthcare providers can work together to find the most effective and safe solutions for managing insomnia.

Date :
  1. Date Completed 2003-10-23
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

12826988

DOI: Digital Object Identifier

10.1097/01.jcp.0000084033.22282.b6

Related Literature

Article Analysis
・Effective treatment of valerian
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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