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[Rat heart transplantation immune tolerance induced by blockade of B7-CD28 interaction].
Author: ChenG, HuangJ, QianY
Original Abstract of the Article :
OBJECTIVE: To study immune tolerance induced by blockade of B7-CD28 interaction after heart transplantation in rats. METHODS: A model of rat heterotopic heart allograft was established by using Ono's technique. CTLA-4-Ig was administered by intraperitoneal injection at dose of 100 micro. Survival t...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/12828181
データ提供：米国国立医学図書館（NLM）
Immune Tolerance: A New Frontier in Organ Transplantation
The field of [organ transplantation] is constantly seeking ways to prevent [immune rejection] and improve long-term graft survival. This study explores the potential of [immune tolerance] induced by [blockade of B7-CD28 interaction] in a [rat heart transplantation model]. The researchers investigated the impact of [CTLA-4-Ig] on [graft survival], [histological changes], and [immune responses]. Their findings offer promising insights into the potential of this approach for achieving long-term graft acceptance.
Blockade of B7-CD28 Interaction: A Powerful Tool for Inducing Immune Tolerance
The study's results demonstrate the efficacy of [CTLA-4-Ig] in inducing [immune tolerance] in a [rat heart transplantation model]. The authors observed significantly prolonged [graft survival times] in the group treated with [CTLA-4-Ig], accompanied by [minimal histological changes] indicative of reduced [immune rejection]. This suggests that [blockade of B7-CD28 interaction] could be a promising strategy for preventing [immune rejection] and achieving long-term graft acceptance.
Navigating the Desert of Immune Rejection: Finding a Path to Tolerance
This research, like a trailblazer venturing into a vast and unforgiving desert, offers a new path toward achieving [immune tolerance] in [organ transplantation]. The study's findings demonstrate the potential of blocking B7-CD28 interaction as a powerful tool for preventing immune rejection and improving graft survival. It is a testament to the ongoing search for innovative approaches to overcome the challenges of organ transplantation and provide long-lasting solutions for patients in need.
Dr.Camel's Conclusion
The desert of immune rejection can be a daunting and treacherous landscape for organ transplant recipients. This study offers a beacon of hope, suggesting that blocking B7-CD28 interaction could pave a path towards immune tolerance. It is a reminder that the quest for better solutions in organ transplantation continues, with new discoveries offering promising avenues for a brighter future.
Date :
- Date Completed 2008-12-22
- Date Revised 2017-11-16
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