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Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk.

Author: AljazafKhalidah, HackettL Peter, HaleThomas W, HartmannPeter E, IlettKenneth F, KristensenJudith H, MitoulasLeon R

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A single dose of pseudoephedrine significantly reduced milk production. However, the calculated infant dose delivered via milk was < 10% of the maternal dose and is unlikely to affect the infant adversely.
Paper Details　
Original Abstract of the Article :
AIMS: To assess the effects of pseudoephedrine on breast blood flow, temperature and milk production, and to estimate the likely infant dose during breastfeeding. METHODS: Eight lactating women (mean age 35 years and weight 69 kg) participated in a single-blind randomized crossover study of 60 mg p...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1046/j.1365-2125.2003.01822.x

データ提供：米国国立医学図書館（NLM）

Pseudoephedrine: A Desert Oasis for Lactating Women

This study delves into the effects of pseudoephedrine, a common decongestant, on breast milk production in women. The authors demonstrate that a single dose of pseudoephedrine significantly reduces milk production, suggesting a potential novel application for the drug. They also estimate the infant exposure to pseudoephedrine through breast milk, finding it to be minimal and unlikely to pose any risks to the infant.

Pseudoephedrine: A Balancing Act for Lactating Mothers

This research sheds light on the complex relationship between pseudoephedrine and breastfeeding. It's like navigating a delicate balance in the desert – finding the right amount of water to stay hydrated without overwhelming the system. The authors demonstrate the potential benefits of pseudoephedrine for mothers while ensuring the safety of their infants.

Understanding the Landscape of Lactation

This study provides valuable insights into the physiological mechanisms involved in lactation and the potential effects of medications on breast milk production. It's like mapping out the intricate landscape of a desert – understanding the terrain allows us to navigate safely and effectively. This research enhances our understanding of lactation and the potential applications of pseudoephedrine.

Dr.Camel's Conclusion

This study offers valuable insights into the effects of pseudoephedrine on lactation, revealing a potential novel application for the drug while ensuring the safety of breastfeeding infants. It's like finding a hidden oasis in the vast desert of medical knowledge – a source of both benefit and caution for mothers seeking to use pseudoephedrine while breastfeeding. This research underscores the importance of understanding the complex interactions between medications and lactation.

Date :
  1. Date Completed 2003-09-16
  2. Date Revised 2019-05-13
Further Info :

Pubmed ID

12848771

DOI: Digital Object Identifier

10.1046/j.1365-2125.2003.01822.x

Related Literature

Article Analysis
・Effects of pseudoephedrine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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