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Effects of aprepitant on cytochrome P450 3A4 activity using midazolam as a probe.

Author: BlumRobert A, ConstanzerMarvin, DruJames, GoldbergMichael R, GottesdienerKeith M, HesneyMichael, LinesChristopher R, MajumdarAnup K, McCreaJacqueline B, MurphyGail, PanebiancoDeborah L, PettyKevin J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Overview

Aprepitant is a medication used to prevent chemotherapy-induced nausea and vomiting. It blocks neurokinin(1) receptors, which are involved in the vomiting reflex. Aprepitant may interact with other medications that are metabolized by CYP3A4, an enzyme in the liver.
Paper Details　
Original Abstract of the Article :
Aprepitant is a neurokinin(1) receptor antagonist that enhances prevention of chemotherapy-induced nausea and vomiting when added to conventional therapy with a corticosteroid and a 5-hydroxytryptamine(3) (5-HT(3)) antagonist. Because aprepitant may be used with a variety of chemotherapeutic agents ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/12891225

データ提供：米国国立医学図書館（NLM）

Aprepitant's Effect on Cytochrome P450 3A4 Activity

This study investigates the impact of aprepitant, a drug used to prevent chemotherapy-induced nausea and vomiting, on the activity of cytochrome P450 3A4 (CYP3A4), an important enzyme in drug metabolism. Imagine a camel's digestive system breaking down food – CYP3A4 is like a key enzyme that helps process and eliminate substances in the body.

Aprepitant and CYP3A4 Activity

The study used midazolam, a drug that is metabolized by CYP3A4, as a probe to assess the effects of aprepitant. The researchers found that aprepitant can inhibit CYP3A4 activity, suggesting that it might interact with other drugs that are metabolized by the same enzyme. This is like a camel's digestive system encountering a new type of plant, potentially affecting its ability to process other foods.

Drug Interactions

This research highlights the importance of considering potential drug interactions when prescribing aprepitant. It's crucial to ensure that the camel's digestive system can handle all the necessary foods without encountering any adverse effects. Doctors should carefully evaluate patients' medication history and potential interactions to avoid any complications.

Dr.Camel's Conclusion

This research underscores the complexity of drug interactions, emphasizing the need for careful consideration of potential side effects. It's like understanding how different plants in the desert ecosystem might interact with each other – a camel might thrive on one type of plant but be harmed by another. This research helps us navigate the intricate world of drug interactions and ensure patient safety.

Date :
  1. Date Completed 2003-08-28
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

12891225

DOI: Digital Object Identifier

S0009923603001231

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・Effects of aprepitant
SNS
PICO Info
in preparation
Languages

English

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