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Antidepressant profile in rodents of SR 58611A, a new selective agonist for atypical beta-adrenoceptors.

Author: BianchettiA, GonalonsN, GuitardJ, KeaneP E, LangloisX, Le FurG, MartinP, SimiandJ, SoubriéP

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

SR 58611A, a selective atypical beta-adrenoceptor agonist, showed antidepressant-like activity in rodents without the peripheral side effects of beta-2 adrenoceptor agonists.
Paper Details　
Original Abstract of the Article :
beta 2-Adrenoceptor agonists possess antidepressant-like activity in animals and man, but their peripheral side-effects prevent their therapeutic use. Atypical beta-adrenoceptors have not been demonstrated in the central nervous system, but are known to exist in peripheral tissues such as the rat co...See full text at original site
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引用元：
https://doi.org/10.1016/0014-2999(92)90296-g

データ提供：米国国立医学図書館（NLM）

Atypical Beta-Adrenoceptors: Discovering New Oasis in the Desert of Depression

The field of mental health is always seeking new and effective treatments for depression. This research investigates the potential of a new class of antidepressant compounds that target atypical beta-adrenoceptors. The authors explored the antidepressant-like effects of SR 58611A, a selective agonist for atypical beta-adrenoceptors, in rodent models. This is like embarking on a journey across a vast desert, searching for a new source of water to sustain life.

SR 58611A: A Potential Oasis in the Desert of Depression

The study found that SR 58611A exhibited antidepressant-like activity in several rodent models. This discovery is like finding a hidden oasis in the heart of the desert, offering a potential solution to the challenges of depression. The compound was particularly effective in reversing learned helplessness, a key symptom of depression.

Navigating the Desert of Mental Health: Exploring New Frontiers

This research is a reminder that the desert of mental health is vast and complex. It's essential to continue exploring new frontiers and seeking innovative treatments for depression. This research offers hope that new pathways to recovery may be found, like discovering a new route through the desert that leads to a thriving oasis.

Dr.Camel's Conclusion

This research is like a camel caravan discovering a new watering hole in the vast desert of depression. It offers a glimmer of hope that new treatments may be on the horizon, providing much-needed relief and opening up new pathways towards recovery.

Date :
  1. Date Completed 1992-12-07
  2. Date Revised 2019-06-23
Further Info :

Pubmed ID

1358639

DOI: Digital Object Identifier

10.1016/0014-2999(92)90296-g

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Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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