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Original Abstract of the Article :
The effects of the clinically used diuretics amiloride (an inhibitor of Na+/H+ exchange) and bumetanide (an inhibitor of Na+, K+, Cl- co-transport) were tested on the cytotoxicity of estramustine and bleomycin in cultured fibroblasts. Both estramustine (50 micrograms/ml) and bleomycin (10 micrograms...See full text at original site
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引用元：
https://doi.org/10.1016/0304-3835(92)90078-a
データ提供：米国国立医学図書館（NLM）
Protecting Against Cell Damage: Amiloride’s Role in Cancer Treatment
Cancer treatment often involves using chemotherapy drugs, which can damage healthy cells along with the cancerous ones. It’s like a powerful desert sandstorm, eroding everything in its path. This research investigates the potential protective effects of amiloride, a diuretic, against the cytotoxic effects of two chemotherapy drugs: estramustine and bleomycin. It’s like discovering a hidden oasis in the desert, offering a potential way to shield healthy cells from the destructive force of the sandstorm.
Amiloride: A Potential Oasis in the Desert of Chemotherapy
The effects of the clinically used diuretics amiloride (an inhibitor of Na+/H+ exchange) and bumetanide (an inhibitor of Na+, K+, Cl- co-transport) were tested on the cytotoxicity of estramustine and bleomycin in cultured fibroblasts. Both estramustine (50 micrograms/ml) and bleomycin (10 micrograms/ml) reduced the number of surviving clones. Amiloride (100 microM) but not bumetanide (100 microM) partly protected against the cytotoxic effect of both estramustine and bleomycin. The protective effect of the combination of amiloride and bumetanide was not stronger than the effect of amiloride alone. Amiloride or bumetanide alone did not affect the clonal survival. It is suggested that the protective effect of amiloride is not mediated by an effect of the molecular mechanism of cytotoxicity but may rather be due to changes in cellular metabolism and/or drug handling.
A Potential Oasis for Cell Protection During Cancer Treatment
This research suggests that amiloride may have a protective effect against the cell damage caused by certain chemotherapy drugs. It's like discovering a hidden oasis in the desert, offering a potential way to shield healthy cells from the destructive force of the sandstorm. Further research is needed to confirm this potential benefit and to determine the optimal use of amiloride in cancer treatment.
Dr.Camel's Conclusion
Amiloride may offer a potential oasis in the desert of chemotherapy, protecting healthy cells from damage. Further research is needed to confirm its protective effects and determine its optimal use in cancer treatment.
Date :
- Date Completed 1992-07-29
- Date Revised 2019-07-20
Further Info :
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