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Low efficacy and high frequency of adverse events in a randomized trial of the triple nucleoside regimen abacavir, stavudine and didanosine.

Author: GerstoftJan, KatzensteinTerese L, KirkOle, LundgrenJens D, MathiesenLars, NielsenHenrik, ObelNiels, PedersenCourt

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The A/S/D regimen had a low efficacy and a high frequency of adverse events and cannot be recommended.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Highly active antiretroviral therapy containing three nucleoside reverse transcriptase inhibitors has been somewhat successful, but the clinical efficacy is unclear. METHODS: Randomized, controlled, open-label trial of 180 antiretroviral drug-naive HIV-infected patients allocated to a r...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1097/00002030-200309260-00005

データ提供：米国国立医学図書館（NLM）

Triple Nucleoside Regimen: A Challenging Journey Through the Desert of HIV Treatment

HIV treatment is a complex journey, much like traversing a vast and unforgiving desert, requiring careful navigation and effective therapies. This research explores the effectiveness and safety of a triple nucleoside regimen, a common treatment approach, in the fight against HIV infection. The study aims to evaluate the efficacy and adverse events associated with a specific triple nucleoside regimen, comparing it to other established treatment options. The researchers found that the triple nucleoside regimen had a low efficacy and a high frequency of adverse events, making it less desirable compared to other established treatments. This study highlights the importance of carefully considering the benefits and risks of different HIV treatment approaches, ensuring the best possible outcomes for patients.

Triple Nucleoside Regimen: A Challenging Path in the Desert of HIV Treatment

This study provides valuable insights into the effectiveness and safety of a specific triple nucleoside regimen, highlighting the need for careful consideration of different treatment approaches in the ongoing fight against HIV infection.

Navigating the Desert of HIV Treatment: Finding the Right Path

The findings suggest that not all treatment approaches are created equal in the desert of HIV treatment. This research underscores the importance of carefully weighing the benefits and risks of different treatment options, ensuring the most effective and safe approach for each individual patient.

Dr.Camel's Conclusion

Navigating the desert of HIV treatment requires careful consideration of the many treatment options available. This study reveals the challenges associated with a specific triple nucleoside regimen, highlighting the importance of choosing the right path to ensure the best possible outcomes for patients facing this complex disease. By understanding the vast landscape of HIV treatment options, we can better support patients on their journey toward a healthier future.

Date :
  1. Date Completed 2003-12-15
  2. Date Revised 2019-07-18
Further Info :

Pubmed ID

14502007

DOI: Digital Object Identifier

10.1097/00002030-200309260-00005

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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