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Randomized, double-masked comparison of olopatadine ophthalmic solution, mometasone furoate monohydrate nasal spray, and fexofenadine hydrochloride tablets using the conjunctival and nasal allergen challenge models.

Author: AbelsonMark B, GotnesPaulo J, OberAndrew, SpanglerDennis L

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that exposure of the nasal mucosa to allergen resulted in allergic rhinitis, and exposure of the ocular surface to allergen resulted in conjunctivitis with a secondary effect in the nose. The topical ophthalmic solution provided the most effective management of allergic ocular signs and symptoms, and the nasal spray was most effective for nasal symptoms.
Paper Details　
Original Abstract of the Article :
BACKGROUND: It is presumed that exposure to allergens in the environment occurs through both the eyes and the nose. Allergic rhinoconjunctivitis is typically treated with a nasal spray or systemic antihistamine, neither of which may provide adequate relief of the ocular component of the disease. OB...See full text at original site
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引用元：
https://doi.org/10.1016/s0149-2918(03)80217-5

データ提供：米国国立医学図書館（NLM）

Allergic Rhinoconjunctivitis: A Cross-Talk Between Eyes and Nose

Allergic rhinoconjunctivitis, a common condition characterized by inflammation of the nasal passages and conjunctiva, can significantly impact quality of life. This study explores the intricate interplay between the ocular and nasal mucosa in allergic rhinoconjunctivitis, investigating the effectiveness of various antihistamine treatments.

The study employed a controlled challenge model to assess the effectiveness of olopatadine ophthalmic solution, mometasone furoate nasal spray, and fexofenadine hydrochloride tablets in reducing ocular and nasal symptoms. The researchers found that olopatadine ophthalmic solution was most effective in reducing ocular itching, while mometasone furoate nasal spray provided superior relief of nasal symptoms. The study also revealed that allergens and antiallergy drugs can travel from the eyes to the nose, highlighting the interconnected nature of these mucosal surfaces.

This study provides valuable insights into the complex interplay between the eyes and nose in allergic rhinoconjunctivitis. It offers a comprehensive assessment of the effectiveness of different antihistamine treatments, emphasizing the importance of targeted therapies for addressing both ocular and nasal symptoms.

Navigating the Labyrinth of Allergic Rhinoconjunctivitis

This study is like a camel caravan navigating a complex labyrinth of allergic responses. The researchers meticulously investigate the interplay between the eyes and nose, seeking the most effective path to alleviate the symptoms of allergic rhinoconjunctivitis.

Tailoring Treatment for Optimal Relief

This research emphasizes the importance of tailoring treatment strategies for allergic rhinoconjunctivitis. The study's findings suggest that combining a topical ophthalmic solution with a nasal spray may provide optimal relief for patients experiencing both ocular and nasal symptoms.

Dr.Camel's Conclusion

The research on allergic rhinoconjunctivitis is like a camel caravan traversing a desert of allergic responses. The researchers meticulously investigate the interplay between the eyes and nose, seeking the most effective path to alleviate symptoms. The study's findings offer valuable insights for developing personalized treatment strategies and optimizing patient care.

Date :
  1. Date Completed 2004-01-08
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

14512132

DOI: Digital Object Identifier

10.1016/s0149-2918(03)80217-5

Related Literature

Article Analysis
・Effects of olopatadine ophthalmic
SNS
PICO Info
in preparation
Languages

English

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