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The use of glyceryl trinitrate (GTN) in the treatment of chronic anal fissure in children.

Author: KapilaLeela, LundJonathan N, ScholefieldJohn H, SimpsonJohn, ThompsonRichard J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Glyceryl trinitrate (GTN) ointment is effective for anal fissures in adults, but headaches are common. This study investigates the safety and efficacy of lower-concentration GTN ointments in children with anal fissures.
Paper Details　
Original Abstract of the Article :
0.2 per cent topical glyceryl trinitrate (GTN) ointment heals up to two-thirds of chronic anal fissures in adults although many patients experience troublesome headaches. This double blind randomised pilot study assessed the efficacy and side effects of 0.1 and 0.05 per cent GTN ointment in treatmen...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/14523338

データ提供：米国国立医学図書館（NLM）

Glyceryl Trinitrate for Anal Fissures in Children: A New Oasis in the Desert of Pediatric Treatment

Anal fissures, painful tears in the lining of the anus, can be a significant source of discomfort for children. This study explores the efficacy and safety of glyceryl trinitrate (GTN) ointment, a medication commonly used for adults with anal fissures, for treating children. The researchers conducted a double-blind, randomized pilot study to assess the effectiveness of 0.1% and 0.05% GTN ointment in children with chronic anal fissures.

A New Approach to Treatment: Tailoring GTN for Pediatric Use

The study found that GTN ointment was effective in healing anal fissures in children, with similar efficacy to adult studies. However, the researchers observed that the lower concentration of GTN (0.05%) was associated with fewer side effects, particularly headaches, which are commonly reported in adults. This finding suggests that a lower concentration of GTN may be a more suitable option for children.

Navigating the Desert of Anal Fissures: A New Hope for Pediatric Patients

This study offers a promising approach to managing anal fissures in children. The findings suggest that GTN ointment can be effective and safe in treating this condition, with a lower concentration potentially minimizing side effects. This research opens up new possibilities for alleviating the discomfort and pain associated with anal fissures in children, providing a much-needed oasis in the desert of pediatric treatment options.

Dr.Camel's Conclusion

This study explores the efficacy and safety of glyceryl trinitrate (GTN) ointment for treating chronic anal fissures in children. The researchers found that GTN ointment was effective in healing anal fissures, with a lower concentration associated with fewer side effects. This research provides a valuable contribution to the field of pediatric gastroenterology, offering a new and promising approach to managing this challenging condition. Just as a camel navigates the vast desert, healthcare providers are constantly seeking new pathways to improve the well-being of their patients.

Date :
  1. Date Completed 2003-12-24
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

14523338

DOI: Digital Object Identifier

3465

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English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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