Effects of metronidazole and tinidazole on NTPDase1 and ecto-5'-nucleotidase from intact cells of Trichomonas vaginalis.

Author: BattastiniAna Maria Oliveira, BonanCarla Denise, BorgesFernanda Pires, De CarliGeraldo Attilio, SarkisJoão José Freitas, TascaTiana

Paper Details 
Original Abstract of the Article :
Here we report the effects of metronidazole and tinidazole on NTPDase1 and ecto-5'-nucleotidase from intact cells of Trichomonas vaginalis. Adenosine triphosphate (ATP) and adenosine diphosphate (ADP) hydrolysis was 5- to 7-fold higher for the fresh clinical strain, when compared with the ATCC (Amer...See full text at original site
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引用元:
https://doi.org/10.1016/S0378-1097(03)00637-2

データ提供:米国国立医学図書館(NLM)

Metronidazole and Tinidazole: Exploring the Impact on Trichomonas vaginalis

Trichomonas vaginalis is a common sexually transmitted parasite that can cause vaginal infections. This study investigates the effects of metronidazole and tinidazole, two commonly used anti-parasitic drugs, on the activity of specific enzymes in T. vaginalis. Understanding these interactions is crucial for developing more effective and targeted treatments for trichomoniasis.

Decoding the Parasitic Response to Treatment

This study delves into the intricate mechanisms by which T. vaginalis responds to treatment with metronidazole and tinidazole. The researchers observed that these drugs can modulate the activity of specific enzymes involved in the parasite's energy production and survival. It's like uncovering a hidden language used by the parasite to communicate with its environment and potentially resist treatment. The researchers found that both drugs can inhibit the activity of certain enzymes, potentially impacting the parasite's ability to survive and multiply.

Navigating Treatment Strategies: A Deeper Understanding

This research offers a deeper understanding of the mechanisms by which metronidazole and tinidazole act against T. vaginalis. It's like having a detailed map of the parasite's inner workings, allowing us to better navigate the complexities of treatment strategies. This knowledge can be crucial in developing new and improved treatments for trichomoniasis.

Dr.Camel's Conclusion

This study sheds light on the complex interplay between anti-parasitic drugs and T. vaginalis. By uncovering the mechanisms of drug action, this research contributes to a more comprehensive understanding of trichomoniasis and its treatment. It's like finding a hidden treasure chest filled with knowledge about parasitic infections, providing valuable insights for future research and development of effective therapies.

Date :
  1. Date Completed 2003-12-17
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

14553936

DOI: Digital Object Identifier

10.1016/S0378-1097(03)00637-2

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English

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