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Antibacterial susceptibility of a vancomycin-resistant Staphylococcus aureus strain isolated at the Hershey Medical Center.

Author: AppelbaumPeter C, BozdoganBulent, BrowneFrederick A, EselDuygu, WhitenerCynthia

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the susceptibility of Staphylococcus aureus strain HMC3, a vancomycin-resistant strain, to various experimental drugs. The researchers found that several drugs, including cephalosporins, glycopeptides, lipopeptides, and new fluoroquinolones, were effective against VRSA HMC3.
Paper Details　
Original Abstract of the Article :
Staphylococcus aureus strain HMC3 isolated at the Hershey Medical Center, was resistant to vancomycin (VRSA) through the presence of the vanA resistance gene; it also contained mecA, erm(A), erm(B), tet(K) and aac(6')-aph(2"), conferring resistance to licensed beta-lactams, macrolides, tetracycline ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/14563898

データ提供：米国国立医学図書館（NLM）

The Evolving Challenge of Antibiotic Resistance: A Case Study of VRSA

Antibiotic resistance poses a growing threat to global health, and vancomycin-resistant Staphylococcus aureus (VRSA) is a prime example of this challenge. This research examines the antibiotic susceptibility of VRSA strain HMC3, highlighting the urgent need for new treatment options. The study identifies several experimental drugs with promising activity against VRSA, offering a glimmer of hope in the battle against antibiotic resistance.

A Battleground for Antibiotic Research

The study's findings underscore the critical need for ongoing research and development of new antibiotics. The identification of potential drugs like cephalosporins BAL9141 and RWJ-54428, glycopeptides oritavancin and dalbavancin, and the lipopeptide daptomycin provides valuable insights for future drug development. The study's results highlight the complexities of tackling antibiotic resistance, demonstrating the importance of collaboration and innovative approaches to overcome this growing threat.

The Importance of Prudent Antibiotic Use

It's essential to remember that antibiotic resistance is a growing concern. The overuse and misuse of antibiotics contribute to this problem. We must work together to ensure that antibiotics are used appropriately and only when necessary, to slow the development of resistance. This research serves as a reminder of the delicate balance between medical advancements and the ever-evolving challenge of antibiotic resistance.

Dr.Camel's Conclusion

This study reveals the persistent challenge of antibiotic resistance, exemplified by the VRSA strain HMC3. It's a reminder that the fight against antibiotic resistance is a constant journey, just as a camel must navigate a shifting desert landscape. The discovery of potential new drugs offers hope, but it's crucial to remain vigilant and promote prudent antibiotic use to preserve the effectiveness of these life-saving medications.
Date :
  1. Date Completed 2004-01-29
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

14563898

DOI: Digital Object Identifier

dkg457

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Languages

English

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