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Intracellular disposition and metabolic effects of zidovudine, stavudine and four protease inhibitors in cultured adipocytes.

Author: BackDavid J, HoggardPatrick G, JannehOmar, JonesSimon P, KhooSaye H, MaherBridget, PirmohamedMunir, TjiaJohn F

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effect of HIV protease inhibitors (PIs) and nucleoside reverse transcriptase inhibitors (NRTIs) on adipocyte metabolism and viability. The study found that PIs accumulated in adipocytes and were cytotoxic, inhibiting adipogenesis, increasing lipolysis, and impairing preadipocyte protein synthesis. PIs also inhibited glucose uptake. In contrast, NRTIs were not cytotoxic and did not affect adipocyte metabolism, but their effects in combination with PIs warrants further investigation.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: The pathogenesis of lipodystrophy caused by the HIV protease inhibitors (PIs) and nucleoside reverse transcriptase inhibitors (NRTIs) is unclear. We have investigated the disposition of these drugs in adipocytes and the consequent effect on adipocyte metabolism and viability. DESIGN: Lab...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/14640389

データ提供：米国国立医学図書館（NLM）

A Balancing Act: HIV Medications and Adipocyte Metabolism

The treatment of HIV infection has revolutionized the lives of countless individuals, but some medications can have unintended consequences. This study investigates the intracellular disposition and metabolic effects of zidovudine, stavudine, and four protease inhibitors in cultured adipocytes. The researchers aimed to understand how these HIV medications affect adipocyte metabolism, potentially contributing to the development of lipodystrophy, a side effect characterized by changes in body fat distribution.

The Complex Interplay of HIV Medications

The study reveals a complex interplay between HIV medications and adipocyte metabolism. While nucleoside reverse transcriptase inhibitors (NRTIs) like zidovudine and stavudine did not show significant adverse effects on adipocyte function, protease inhibitors (PIs) were found to accumulate in adipocytes and disrupt adipogenesis, lipolysis, and glucose uptake, potentially contributing to the development of lipodystrophy. This research provides valuable insights into the mechanisms by which HIV medications can affect body fat distribution.

Navigating the Side Effects of HIV Treatment

This study highlights the importance of monitoring patients receiving HIV treatment for potential side effects, particularly lipodystrophy. The researchers' findings emphasize the need for a personalized approach to HIV treatment, carefully considering the potential metabolic effects of different medication combinations. This research encourages ongoing research into the development of new HIV medications with fewer side effects and more favorable metabolic profiles.

Dr.Camel's Conclusion

The treatment of HIV infection is a complex journey, requiring careful consideration of both benefits and risks. This research, like a compass guiding a traveler through the vast desert of medical knowledge, sheds light on the potential metabolic effects of HIV medications. It reminds us that while medications can offer hope and healing, it's essential to be mindful of their potential side effects, ensuring that patients receive the best possible care and support throughout their treatment journey.

Date :
  1. Date Completed 2004-02-09
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

14640389

DOI: Digital Object Identifier

14640389

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Languages

English

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