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Furosemide continuous rate infusion in the horse: evaluation of enhanced efficacy and reduced side effects.

Author: AtkinsClarke E, FuquayLaura R, GardnerSarah Y, JohanssonAnna M, LaFeversD Heath, LevineJay F, PapichMark G, ReaganVirginia H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Continuous rate infusion (CRI) of furosemide was compared to intermittent administration (IA) in horses. CRI produced a more uniform urine flow, decreased fluctuations in plasma volume, and suppressed renal concentrating ability. It also resulted in greater potassium, calcium, and chloride excretion. CRI is recommended when profound diuresis is needed acutely in horses.
Paper Details　
Original Abstract of the Article :
Continuous rate infusion (CRI) of furosemide in humans is considered superior to intermittent administration (IA). This study examined whether furosemide CRI, compared with IA, would increase diuretic efficacy with decreased fluid and electrolyte fluctuations and activation of the renin-angiotensin-...See full text at original site
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引用元：
https://doi.org/10.1111/j.1939-1676.2003.tb02529.x

データ提供：米国国立医学図書館（NLM）

Furosemide: Enhancing Efficacy and Reducing Side Effects

This study investigates the effectiveness of continuous rate infusion (CRI) of furosemide, a potent diuretic, in horses compared to intermittent administration (IA). The researchers compared the two methods, focusing on urine volume, fluid and electrolyte balance, and activation of the renin-angiotensin-aldosterone system (RAAS), a key hormonal system involved in blood pressure regulation. The results suggest that CRI of furosemide may offer enhanced efficacy and reduced side effects in horses compared to IA.

Furosemide: A More Efficient and Safer Approach

The study's findings suggest that CRI of furosemide may be a more efficient and safer approach for managing fluid overload in horses. CRI produced a more uniform urine flow, minimizing fluctuations in plasma volume and potentially reducing the risk of electrolyte imbalances. However, further research is needed to confirm these benefits and determine the optimal dosage and duration of CRI for horses.

Optimizing Treatment Strategies: A Case for Personalized Approaches

This research emphasizes the importance of tailoring treatment strategies to individual patients, considering their specific needs and potential risks. The findings suggest that CRI of furosemide may be a more effective and safer approach for certain conditions, but it's crucial to weigh the benefits and risks carefully and consider alternative approaches when appropriate.

Dr. Camel's Conclusion

This study delves into the complexities of drug delivery methods, demonstrating that even seemingly minor adjustments can significantly impact effectiveness and safety. It's like navigating a desert landscape where choosing the right path can make all the difference in reaching your destination safely and efficiently. This research underscores the importance of continuous innovation and refinement in medical practices to optimize patient care.

Date :
  1. Date Completed 2004-03-23
  2. Date Revised 2019-05-13
Further Info :

Pubmed ID

14658727

DOI: Digital Object Identifier

10.1111/j.1939-1676.2003.tb02529.x

Related Literature

Article Analysis
・Side Effects of furosemide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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