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Palliative therapy of disseminated malignant melanoma: a systematic review of 41 randomised clinical trials.

Author: CaroliUlrich M, EigentlerThomas K, GarbeClaus, RadnyPeter

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

The review of randomized studies in disseminated melanoma found that while some treatment regimens, particularly polychemotherapy schedules, seem to increase response rates, none were proven to prolong overall survival. Patients should be treated with well-tolerated regimens, and new treatment concepts should be thoroughly investigated in randomized trials.
Paper Details　
Original Abstract of the Article :
We undertook a systematic review of 41 randomised studies in disseminated melanoma, identified by a comprehensive search. We aimed to investigate rates of response to various treatment modalities and the outcome for the patients. We analysed seven studies that compared polychemotherapy with single-a...See full text at original site
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引用元：
https://doi.org/10.1016/s1470-2045(03)01280-4

データ提供：米国国立医学図書館（NLM）

Disseminated Melanoma: A Search for Effective Treatments

This systematic review, a veritable treasure map in the realm of melanoma research, analyzed 41 randomized clinical trials investigating various treatment modalities for disseminated melanoma. The researchers focused on identifying the most effective treatments and their impact on patient outcomes. Although the review uncovered several promising treatment regimens, especially polychemotherapy schedules, none were definitively proven to prolong overall survival. The researchers emphasize the importance of continued research and randomized trials to explore new treatment concepts and their potential benefits in the fight against this challenging disease.

The Need for Personalized and Evidence-Based Treatment

The researchers advocate for the use of well-tolerated drug regimens, such as single-agent treatments or combinations with interferon alfa, to manage disseminated melanoma. This highlights the importance of personalized medicine, where treatments are tailored to individual patients and their specific needs. The review also reinforces the crucial role of clinical trials in evaluating the efficacy of new treatments and ensuring that patients receive the best possible care.

Navigating the Shifting Sands of Melanoma Treatment

Like a skilled traveler navigating the ever-shifting sands of the desert, researchers in this field continuously seek the most effective paths to combat this formidable disease. The pursuit of personalized treatments and robust clinical trials remains crucial in the ongoing battle against melanoma, aiming to provide patients with the best possible chance of survival.

Dr.Camel's Conclusion

This systematic review of disseminated melanoma treatment provides valuable insights into the challenges and complexities of this disease. The findings highlight the need for personalized treatment approaches and continued research to identify more effective therapies. By embracing a collaborative and evidence-based approach, researchers and clinicians can work together to navigate the shifting sands of melanoma treatment and improve outcomes for patients.
Date :
  1. Date Completed 2003-12-24
  2. Date Revised 2020-12-26
Further Info :

Pubmed ID

14662431

DOI: Digital Object Identifier

10.1016/s1470-2045(03)01280-4

Related Literature

Article Analysis
・Effective treatment of melanoma
SNS
PICO Info
in preparation
Languages

English

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