Paper Details

  1. Home
  2. Paper Details

Comparison of nitroglycerin with nifedipine in patients with hypertensive crisis or severe hypertension.

Author: BussmannW D, KenediP, NastH P, RachorN, von MengdenH J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Nitroglycerin is more effective than nifedipine in lowering blood pressure in severe hypertension and hypertensive crisis.
Paper Details　
Original Abstract of the Article :
To determine whether nitroglycerin is as effective as nifedipine in lowering the blood pressure in severe hypertension and hypertensive crisis, two groups of 20 patients received in random sequence either 1.2 mg nitroglycerin sublingually or a 10-mg nifedipine capsule, which was chewed and swallowed...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1007/BF00184550

データ提供：米国国立医学図書館（NLM）

Nitroglycerin vs. Nifedipine: Which is Best for Hypertensive Crisis?

This study compares the effectiveness of nitroglycerin and nifedipine in treating severe hypertension and hypertensive crisis. Both medications are commonly used to lower blood pressure, but the study investigates whether one is more effective than the other in emergency situations. The researchers compared the effects of these drugs on blood pressure and heart rate in a group of patients experiencing hypertensive episodes.

Nitroglycerin: A Rapid Response for Hypertensive Crisis

The study demonstrates that nitroglycerin works more quickly than nifedipine in lowering blood pressure during hypertensive crisis. This finding is important because it suggests that nitroglycerin might be the preferred treatment in emergency situations where rapid blood pressure reduction is crucial. Imagine a desert traveler facing a sudden sandstorm: nitroglycerin acts as a quick shield, offering protection against the immediate threat of high blood pressure.

Heart Health: A Balance of Blood Pressure and Heart Rate

The study also reveals that while nitroglycerin effectively lowers blood pressure, it can also cause a decrease in heart rate, which is generally a desirable effect. However, nifedipine can increase heart rate, which might not be suitable for all patients, especially those with heart conditions. Finding the right balance between blood pressure control and heart rate is crucial for optimal cardiovascular health. It's like a delicate dance between the dunes of blood pressure and the oasis of heart rate, maintaining a harmonious rhythm for a healthy heart.

Dr.Camel's Conclusion

This study suggests that nitroglycerin might be a more effective and rapid-acting treatment for hypertensive crisis compared to nifedipine. However, the choice of medication should be tailored to individual patients' needs and underlying health conditions, considering the effects on both blood pressure and heart rate.
Date :
  1. Date Completed 1993-01-26
  2. Date Revised 2019-10-28
Further Info :

Pubmed ID

1467634

DOI: Digital Object Identifier

10.1007/BF00184550

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.