Paper Details

  1. Home
  2. Paper Details

Methadone versus morphine as a first-line strong opioid for cancer pain: a randomized, double-blind study.

Author: BertolinoMariela, BosnjakSnezana, BrueraEduardo, FischMichael J, MathiasClarissa, MoyanoJairo, PalmerJ Lynn, RicoMaria Antonieta, SpruytOdette, StrasserFlorian, SweeneyCatherine, WilleyJie

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Methadone did not provide superior analgesic efficacy or tolerability compared to morphine for first-line treatment of cancer pain. Both treatments resulted in similar pain reduction and global benefit, but methadone had a higher rate of opioid-related drop-outs.
Paper Details　
Original Abstract of the Article :
PURPOSE: To compare the effectiveness and side effects of methadone and morphine as first-line treatment with opioids for cancer pain. PATIENTS AND METHODS: Patients in international palliative care clinics with pain requiring initiation of strong opioids were randomly assigned to receive methadone...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/14701781

データ提供：米国国立医学図書館（NLM）

Methadone vs. Morphine for Cancer Pain: A Head-to-Head Comparison

Cancer pain is a significant challenge for many patients. This randomized, double-blind study compares the effectiveness and side effects of methadone and morphine, two commonly used opioids, in managing cancer pain. It's like a carefully controlled experiment in a desert laboratory, comparing two potential solutions for alleviating pain.

No Clear Winner in the Pain Management Arena

The study finds that both methadone and morphine are effective in reducing pain intensity, but methadone was associated with more opioid-related drop-outs. These findings suggest that both medications can be valuable tools for managing cancer pain, but careful consideration should be given to individual patient factors, such as tolerance and potential side effects. It's like navigating a winding desert path, choosing the route that best suits the individual traveler.

Choosing the Right Path for Pain Relief

This research highlights the importance of individualized pain management, considering the unique needs and preferences of each patient. Consulting with a healthcare professional is crucial to determine the most effective treatment plan, just like a guide leading a caravan through a challenging terrain.

Dr.Camel's Conclusion

This study, like a caravan carefully navigating a vast and challenging landscape, reveals the complexities of pain management. While both methadone and morphine offer potential relief, it's crucial to work with healthcare providers to determine the most appropriate treatment option for each individual.

Date :
  1. Date Completed 2004-01-27
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

14701781

DOI: Digital Object Identifier

22/1/185

Related Literature

Article Analysis
・Effects of morphine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.