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Attempted prevention of blast crisis in chronic myeloid leukemia by the use of pulsed doses of cytarabine and lomustine. A Cancer and Leukemia Group B study.

Author: BrunnerK, DearK B, HauraniF, HollandJ F, KaranasA, SilverR T, WeilM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

A study of patients with chronic myeloid leukemia (CML) investigated the use of cytarabine and lomustine to prevent the development of blast crisis, a more aggressive phase of the disease. The study found that this combination was not more effective than standard treatment with busulfan. The combination therapy was associated with significant gastrointestinal side effects, leading to early discontinuation of treatment. However, the study design allowed patients to quickly switch to conventional treatment if needed. The study found no evidence that the experimental drug combination negatively affected the effectiveness of future conventional therapies. The study provides a framework for future research on CML, particularly with the development of new treatments like interferons.
Paper Details　
Original Abstract of the Article :
An attempt to prevent the blast crisis in chronic myeloid leukemia by the use of pulsed doses of (cytarabine cytosine arabinoside) and lomustine was attempted as a cooperative group study by Cancer and Leukemia Group B. The basis for this study was to delay the development of blast crisis by pulsing...See full text at original site
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引用元：
https://doi.org/10.3109/10428199209053603

データ提供：米国国立医学図書館（NLM）

Preventing Blast Crisis in Chronic Myeloid Leukemia: A Race Against Time in the Desert of Cancer

This research delves into the challenging world of chronic myeloid leukemia (CML), a disease as relentless as a sandstorm. The researchers explore the potential of pulsed doses of cytarabine and lomustine to prevent the dreaded blast crisis, a stage of CML as dangerous as a desert mirage. Employing a clinical trial design, a methodology as meticulous as planning a caravan route, the researchers investigated the impact of this drug combination on CML patients. Their findings reveal that while the combination did not demonstrate superiority to conventional treatment, it did not compromise patient outcomes, highlighting the importance of exploring new therapeutic approaches. This discovery could be as impactful as finding a hidden oasis in the desert of cancer treatment, offering hope for patients facing this challenging disease.

A Search for New Horizons: Navigating the Desert of CML Treatment

The research highlights the ongoing challenges of managing CML, a disease as unforgiving as the desert. The study found that while the combination of cytarabine and lomustine did not achieve superior results to conventional treatment, it did not negatively impact patient outcomes, suggesting that exploration of new treatment strategies is crucial. This discovery could be as significant as discovering a new source of water in the desert, providing valuable information for improving patient care.

Navigating the Desert of CML: A Journey Through the Labyrinth of Cancer Treatment

This research provides valuable information for individuals diagnosed with CML. The study underscores the importance of discussing treatment options with their doctors, just as a camel would rely on its instincts to find the safest path through the desert. The findings highlight the need for ongoing research to develop more effective treatments for this challenging disease, a quest as ambitious as traversing a vast desert landscape.

Dr.Camel's Conclusion

This research provides valuable insights into the challenges of managing chronic myeloid leukemia, a disease as relentless as a sandstorm. The study’s findings underscore the importance of exploring new therapeutic approaches, a quest as ambitious as traversing a vast desert landscape.

Date :
  1. Date Completed 1993-02-02
  2. Date Revised 2019-01-16
Further Info :

Pubmed ID

1472933

DOI: Digital Object Identifier

10.3109/10428199209053603

Related Literature

Article Analysis
・Effective treatment of chronic myeloid leukemia
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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