Synthesis and pharmacological evaluation of some phenothiazines as antidepressants.

Author: KhannaR, PalitG, ShankerK, SinghV, SrivastavaV K

Paper Details 
Original Abstract of the Article :
10-Hydrazino acetyl phenothiazine (II) has been converted to N-10-acetyl amino phenothiazine-N-phenyl thiourea (III) which have been converted to 3-aryl-1-(10-phenothiazine acetyl amino)-2,3-dihydro-2-thioxo-4,6-(1H,5H) pyrimidinones (IV) on condensation with aryl amines and aryl aldehydes yielded 3...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/1497683

データ提供:米国国立医学図書館(NLM)

Phenothiazines: Exploring New Antidepressant Potential

The search for effective and safe antidepressants continues to be a crucial endeavor in the field of mental health. This study investigates the potential antidepressant activity of various phenothiazine derivatives, exploring their therapeutic potential and comparing their efficacy to existing tricyclic antidepressants. It's like a camel traversing a vast desert of chemical compounds, seeking to uncover new and potent therapeutic agents for combating mental illness.

Phenothiazine Derivatives: Potential Antidepressant Activity

The study found that several phenothiazine derivatives exhibited significant antidepressant activity in experimental models, surpassing the efficacy of imipramine, a widely used tricyclic antidepressant. These findings suggest that phenothiazines may offer a promising alternative for treating depression, potentially providing a new avenue for developing effective and well-tolerated medications.

New Horizons in Antidepressant Research

This study highlights the importance of exploring new and innovative approaches to treating depression. It's like discovering a new oasis in a desert of conventional therapies, offering hope and a path toward developing more effective and safe medications for those struggling with mental illness. This research encourages continued exploration and innovation in the search for new and improved antidepressants.

Dr.Camel's Conclusion

This research offers a promising glimpse into the future of antidepressant treatment. It's like finding a hidden treasure trove of therapeutic potential in the vast desert of chemical compounds. This study encourages continued exploration and innovation, seeking to provide a brighter future for those grappling with mental illness.

Date :
  1. Date Completed 1992-09-10
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

1497683

DOI: Digital Object Identifier

1497683

Related Literature

SNS
PICO Info
in preparation
Languages

English

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