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Pharmacokinetic enhancement of protease inhibitor therapy.

Author: AcostaEdward P, BrundageRichard, KingJennifer R, WynnHeather

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Dual protein inhibitor (PI) regimens, like lopinavir/ritonavir, are used in the treatment of HIV infection. The combination of protease inhibitors with low-dose ritonavir has been shown to increase plasma trough concentrations of the protease inhibitors, leading to improved efficacy and reduced pill burden, food restrictions, and side effects.
Paper Details　
Original Abstract of the Article :
Combination antiretroviral therapy with two or more protease inhibitors has become the standard of care in the treatment of HIV infection. Dual protein inhibitor (PI) regimens, such as lopinavir/ritonavir, are commonly used as initial PI therapy. As viral resistance increases and the development of ...See full text at original site
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引用元：
https://doi.org/10.2165/00003088-200443050-00003

データ提供：米国国立医学図書館（NLM）

Boosting Protease Inhibitor Therapy: A Pharmacokinetic Enhancement

The treatment of HIV infection has significantly advanced with the development of protease inhibitors (PIs). This research explores the pharmacokinetic enhancement of PI therapy, specifically focusing on the use of ritonavir, a cytochrome P450 (CYP) enzyme inhibitor, to increase the effectiveness of PIs. The study reviews the mechanisms by which ritonavir enhances PI concentrations and discusses the clinical implications of this approach.

Ritonavir's Potent Enhancement of PI Efficacy

The study explains that ritonavir, when co-administered with PIs, can significantly enhance their pharmacokinetic profile. This enhancement leads to increased PI concentrations, potentially improving treatment efficacy and reducing the development of drug resistance. This approach offers a promising strategy to optimize PI therapy for HIV-infected patients.

Optimizing HIV Treatment: A Pharmacokinetic Approach

This research highlights the importance of understanding pharmacokinetic interactions in optimizing drug therapy. By leveraging the enhancing effect of ritonavir, clinicians can potentially improve the effectiveness of PI therapy, leading to better outcomes for HIV-infected patients.

Dr.Camel's Conclusion

Just as a camel caravan might utilize a well-timed sandstorm to its advantage, this research explores the potential of ritonavir, like a powerful wind, to boost the effectiveness of protease inhibitor therapy. This approach offers a glimpse of a more effective journey through the desert of HIV treatment, potentially leading to a more manageable and hopeful future for infected individuals.

Date :
  1. Date Completed 2004-08-12
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

15080763

DOI: Digital Object Identifier

10.2165/00003088-200443050-00003

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