Dissociation of morphine analgesia and sedation evaluated by EEG measures in healthy volunteers.

Author: BrommBurkhard, Langer-BrauburgerBirgit, QuanteMarkus, SchareinEkehard, ZimmermannRoger

Paper Details 
Original Abstract of the Article :
The analgesic effects of morphine (CAS 57-27-2) in clinical use are well described. Sedation is discussed as a relevant side-effect, mostly based on data recorded in normal subjects without pain. The aim of this study was to quantify and to evaluate electrophysiologically the analgesic and sedative ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1055/s-0031-1296951

データ提供:米国国立医学図書館(NLM)

Dissociation of Morphine Analgesia and Sedation: An Electrophysiological Perspective

Morphine is a widely used pain reliever, but it's also known to cause sedation. This study delves into the complex relationship between morphine's analgesic and sedative effects, utilizing electroencephalography (EEG) to measure brain activity in healthy volunteers.

Morphine: Separating Pain Relief from Sedation

The authors used an experimental pain model to assess the analgesic and sedative effects of morphine. They found that while morphine effectively reduced pain, it also caused sedation, as measured by EEG changes. These findings suggest that morphine's analgesic and sedative effects are distinct, providing valuable insights into the mechanism of action of this commonly used medication.

Navigating the Desert of Pain Management: Understanding the Nuances

This research, like a camel traversing a desert landscape, reminds us of the importance of understanding the nuances of pain management medications. Morphine's dual effects on pain and sedation require careful consideration, particularly when optimizing treatment for individual patients. This research encourages further investigation to identify potential strategies for minimizing sedation while maximizing pain relief, ensuring a more comfortable and effective experience for patients.

Dr. Camel's Conclusion

This study, like a camel navigating the complex and shifting sands of pain management, provides a deeper understanding of morphine's effects on the brain. It separates morphine's analgesic and sedative effects, highlighting the need for careful consideration when prescribing this medication. This research encourages further investigation into strategies for maximizing pain relief while minimizing sedation, improving the overall experience for patients.

Date :
  1. Date Completed 2004-05-24
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

15112860

DOI: Digital Object Identifier

10.1055/s-0031-1296951

Related Literature

Article Analysis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.