Bismuth subsalicylate increases intracellular Ca2+, MAP-kinase activity, and cell proliferation in normal human gastric mucous epithelial cells.

Author: BaconKathy, DeveneyClifford, GilsterJason, MarlinkKatie, RuttenMichael, SheppardBrett

Paper Details 
Original Abstract of the Article :
Clinical and laboratory studies have shown that bismuth subsalicylate (BSS) is helpful in the healing of gastric ulcers because of the bactericidal effects of bismuth (Bi3+) on H. pylori. Bismuth or BSS has also been reported to possess other nonbactericidal or "gastroprotective" effects in the stom...See full text at original site
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引用元:
https://doi.org/10.1023/b:ddas.0000020488.55854.99

データ提供:米国国立医学図書館(NLM)

Bismuth Subsalicylate's Role in Gastric Mucous Epithelial Cell Proliferation

Bismuth subsalicylate (BSS), a common remedy for stomach upset, has been known to fight H. pylori bacteria, a major cause of peptic ulcers. But this study delves deeper, exploring BSS's potential to promote gastric mucosal cell growth. Researchers found that BSS increases intracellular calcium levels, activates specific MAP kinases, and stimulates the proliferation of normal human gastric mucous epithelial cells. This suggests that BSS might offer additional benefits beyond its antibacterial properties.

BSS's Potential to Heal Gastric Mucosa

The findings suggest that BSS may have a role in promoting the healing of damaged gastric mucosa, potentially accelerating recovery from ulcers and other gastric ailments. This is a promising discovery in the vast desert of gastrointestinal research, potentially leading to more effective treatments for stomach problems.

BSS's Potential for Gastric Health

This study suggests that BSS could be a valuable tool for promoting gastric health, offering not only antibacterial protection but also potential healing effects. This is a significant finding that may lead to a better understanding of the mechanisms underlying gastric mucosal healing and potentially to the development of more effective treatments for gastric disorders.

Dr.Camel's Conclusion

This study reveals that BSS may possess a previously unrecognized ability to promote gastric mucous epithelial cell growth, potentially contributing to the healing of gastric ulcers. This discovery is like uncovering a hidden spring in the desert of gastric health, offering a new perspective on BSS's potential therapeutic effects.

Date :
  1. Date Completed 2004-06-01
  2. Date Revised 2019-07-21
Further Info :

Pubmed ID

15139483

DOI: Digital Object Identifier

10.1023/b:ddas.0000020488.55854.99

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PICO Info
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Languages

English

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