Toxic effects of mebendazole at high dose on the haematology of red-legged pademelons (Thylogale stigmatica).

Author: BergerL, JohnsonP M, SkerrattL F, SpeareR

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To investigate the effects of mebendazole at high dose on the haematology of macropods. Experimental. PROCEDURE: Five red-legged pademelons (Thylogale stigmatica) were dosed orally with mebendazole at 50 mg/kg/d for 5 to 6 days. Two control pademelons were dosed with water. Regular blood...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1111/j.1751-0813.2004.tb12710.x

データ提供:米国国立医学図書館(NLM)

Mebendazole: A Cautionary Tale for Macropod Health

Mebendazole, a commonly used antiparasitic medication, has been a valuable tool in controlling parasitic infections in various animal species. This study, like a vigilant explorer carefully observing the impact of a new substance on a delicate ecosystem, investigates the effects of high-dose mebendazole on the haematology of red-legged pademelons, a species of macropod native to Australia. The researchers documented the haematological changes experienced by these animals after receiving high doses of mebendazole, highlighting the potential risks associated with this medication.

A Delicate Balance: Mebendazole and Macropod Health

The study, like a warning sign in a desert landscape, reveals a significant risk associated with high-dose mebendazole administration in red-legged pademelons. The researchers observed severe haematological abnormalities, including leucopenia, neutropenia, thrombocytopenia, and bone marrow aplasia, leading to systemic infections and death in the treated animals. This research emphasizes the importance of careful dosing and monitoring when using mebendazole in macropods,

Navigating the Desert of Animal Health: Avoiding Unforeseen Consequences

This study serves as a reminder of the importance of considering the potential risks and benefits of any medication, especially when used in non-human species. It underscores the need for responsible and evidence-based practices in veterinary medicine, ensuring the safety and well-being of animals under our care.

Dr.Camel's Conclusion

This study highlights the importance of responsible medication use in veterinary medicine. By carefully considering the potential risks and benefits of medications, veterinarians can ensure the health and well-being of their patients, protecting them from unforeseen consequences.

Date :
  1. Date Completed 2004-07-02
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

15181932

DOI: Digital Object Identifier

10.1111/j.1751-0813.2004.tb12710.x

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.